Dopamine receptor D₁

DRD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OZ5
Identifiers
Aliases	DRD1, dopamine receptor D1, DADR, DRD1A
External IDs	OMIM: 126449 MGI: 99578 HomoloGene: 30992 GeneCards: DRD1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	175,444,182 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,209,724 bp
RNA expression pattern
	Top expressed in
	caudate nucleus; ; nucleus accumbens; ; putamen; ; prefrontal cortex; ; Brodmann area 9; ; cingulate gyrus; ; Brodmann area 46; ; amygdala; ; orbitofrontal cortex; ; middle frontal gyrus;
	Top expressed in
	nucleus accumbens; ; olfactory tubercle; ; globus pallidus; ; superior frontal gyrus; ; temporal lobe; ; amygdala; ; urethra; ; suprachiasmatic nucleus; ; piriform cortex; ; prefrontal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	dopamine neurotransmitter receptor activity; dopamine binding; protein binding; dopamine neurotransmitter receptor activity, coupled via Gs; G protein-coupled receptor activity; signal transducer activity; G-protein alpha-subunit binding;
Cellular component	membrane; nucleus; endoplasmic reticulum; integral component of membrane; plasma membrane; endoplasmic reticulum membrane; integral component of plasma membrane; ciliary membrane; endomembrane system; non-motile cilium; glutamatergic synapse; GABA-ergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; dendritic spine; dendrite; cell projection; cilium;
Biological process	positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; muscle contraction; protein import into nucleus; positive regulation of potassium ion transport; response to amphetamine; learning; feeding behavior; long-term depression; temperature homeostasis; striatum development; prepulse inhibition; response to cocaine; grooming behavior; behavioral response to cocaine; locomotory behavior; dentate gyrus development; transmission of nerve impulse; memory; positive regulation of synaptic transmission, glutamatergic; synapse assembly; habituation; adult walking behavior; peristalsis; cellular response to catecholamine stimulus; adenylate cyclase-activating dopamine receptor signaling pathway; regulation of dopamine uptake involved in synaptic transmission; associative learning; astrocyte development; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; positive regulation of release of sequestered calcium ion into cytosol; mating behavior; behavioral fear response; activation of adenylate cyclase activity; dopamine receptor signaling pathway; conditioned taste aversion; cerebral cortex GABAergic interneuron migration; glucose import; visual learning; sensitization; positive regulation of cell migration; operant conditioning; vasodilation; regulation of dopamine metabolic process; dopamine metabolic process; phospholipase C-activating dopamine receptor signaling pathway; maternal behavior; dopamine transport; hippocampus development; neuronal action potential; long-term potentiation; signal transduction; synaptic transmission, dopaminergic; positive regulation of gene expression; cellular response to dopamine; regulation of protein phosphorylation; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of synaptic vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	1812
	13488
	ENSG00000184845
	ENSMUSG00000021478
	P21728
	Q61616
	NM_000794
	NM_001291801; NM_010076
	NP_000785
	NP_001278730; NP_034206
	Wikidata
View/Edit Human	View/Edit Mouse

Dopamine receptor D₁, also known as DRD1. It is one of the two types of D₁-like receptor family — receptors D₁ and D₅. It is a protein that in humans is encoded by the DRD1 gene.

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Dopamine receptor D1

Dopamine receptor D₁