Glial cell line-derived neurotrophic factor

GDNF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2V5E, 3FUB, 4UX8
Identifiers
Aliases	GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
External IDs	OMIM: 600837 MGI: 107430 HomoloGene: 433 GeneCards: GDNF
Gene location (Human)
Chr.	Chromosome 5 (human)
End	37,840,041 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	7,867,056 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; gastric mucosa; ; vastus lateralis muscle; ; smooth muscle tissue; ; transverse colon; ; rectum; ; stromal cell of endometrium;
	Top expressed in
	medullary collecting duct; ; renal corpuscle; ; Hindgut; ; Bowman's capsule; ; genitourinary system; ; vas deferens; ; ureter; ; tongue; ; pharyngeal pouch; ; cumulus cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; growth factor activity; signaling receptor binding; chemoattractant activity involved in axon guidance;
Cellular component	extracellular region; intracellular anatomical structure; extracellular space;
Biological process	peristalsis; ureteric bud development; regulation of dopamine uptake involved in synaptic transmission; peripheral nervous system development; sympathetic nervous system development; organ induction; adult locomotory behavior; positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis; regulation of stem cell differentiation; regulation of morphogenesis of a branching structure; mesenchymal to epithelial transition involved in metanephros morphogenesis; negative regulation of apoptotic process; nervous system development; positive regulation of monooxygenase activity; enteric nervous system development; mRNA stabilization; branching involved in ureteric bud morphogenesis; postganglionic parasympathetic fiber development; positive regulation of dopamine secretion; neural crest cell migration; postsynaptic membrane organization; positive regulation of cell population proliferation; positive regulation of cell differentiation; positive regulation of ureteric bud formation; ureteric bud formation; regulation of gene expression; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; metanephros development; neuron projection development; signal transduction; positive regulation of transcription by RNA polymerase II; MAPK cascade; axon guidance; negative regulation of neuron apoptotic process; positive regulation of branching involved in ureteric bud morphogenesis; regulation of signaling receptor activity; dorsal spinal cord development; embryonic organ development; chemoattraction of axon; commissural neuron axon guidance; regulation of semaphorin-plexin signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2668
	14573
	ENSG00000168621
	ENSMUSG00000022144
	P39905
	P48540
NM_000514; NM_001190468; NM_001190469; NM_001278098; NM_199231;
	NM_199234
	NM_010275; NM_001301332; NM_001301333; NM_001301357
	NP_000505; NP_001177397; NP_001177398; NP_001265027; NP_954701
	NP_001288261; NP_001288262; NP_001288286; NP_034405
	Wikidata
View/Edit Human	View/Edit Mouse

Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. It signals through GFRα receptors, particularly GFRα1. It is also responsible for the determination of spermatogonia into primary spermatocytes, i.e. it is received by RET proto-oncogene (RET) and by forming gradient with SCF it divides the spermatogonia into two cells. As the result there is retention of spermatogonia and formation of spermatocyte.

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