RET proto-oncogene

RET
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IVS, 2IVT, 2IVU, 2IVV, 2X2K, 2X2L, 2X2M, 2X2U, 4CKI, 4CKJ, 4UX8, 5AMN
Identifiers
Aliases	RET, Ret, PTC, RET51, RET9, c-Ret, CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, RET-ELE1, ret proto-oncogene
External IDs	OMIM: 164761 MGI: 97902 HomoloGene: 7517 GeneCards: RET
Gene location (Human)
Chr.	Chromosome 10 (human)
End	43,130,351 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	118,174,679 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; pons; ; tibialis anterior muscle; ; superior vestibular nucleus; ; parotid gland; ; cerebellar vermis; ; prefrontal cortex; ; hypothalamus; ; right adrenal gland;
	Top expressed in
	ventral tegmental area; ; substantia nigra; ; facial motor nucleus; ; enteric nervous system; ; submandibular gland; ; trigeminal ganglion; ; anterior horn of spinal cord; ; medial vestibular nucleus; ; thyroid gland; ; adrenal medulla;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; calcium ion binding; protein kinase activity; kinase activity; protein binding; protein tyrosine kinase activity; ATP binding; signaling receptor activity; transmembrane receptor protein tyrosine kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; endosome; intracellular membrane-bounded organelle; membrane; receptor complex; integral component of plasma membrane; axon; neuronal cell body; dendrite; early endosome; membrane raft; endosome membrane; plasma membrane; cytosol; plasma membrane protein complex; cytoplasm;
Biological process	cellular response to retinoic acid; ureteric bud development; embryonic epithelial tube formation; membrane protein proteolysis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of cell migration; neuron cell-cell adhesion; nervous system development; neuron maturation; positive regulation of metanephric glomerulus development; positive regulation of transcription, DNA-templated; regulation of axonogenesis; protein phosphorylation; enteric nervous system development; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; regulation of cell adhesion; lymphocyte migration into lymphoid organs; cell adhesion; positive regulation of gene expression; ureter maturation; response to pain; retina development in camera-type eye; neural crest cell migration; neuron differentiation; positive regulation of cell size; positive regulation of neuron projection development; posterior midgut development; positive regulation of cell adhesion mediated by integrin; innervation; positive regulation of neuron maturation; activation of cysteine-type endopeptidase activity involved in apoptotic process; signal transduction; homophilic cell adhesion via plasma membrane adhesion molecules; Peyer's patch morphogenesis; peptidyl-tyrosine phosphorylation; MAPK cascade; axon guidance; positive regulation of peptidyl-serine phosphorylation of STAT protein; glial cell-derived neurotrophic factor receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of protein kinase B signaling; negative regulation of signal transduction; cell differentiation; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	5979
	19713
	ENSG00000165731
	ENSMUSG00000030110
	P07949
	P35546
	NM_000323; NM_020629; NM_020630; NM_020975; NM_001355216
	NM_001080780; NM_009050
	NP_065681; NP_066124; NP_001342145; NP_066124.1
	NP_001074249; NP_033076
	Wikidata
View/Edit Human	View/Edit Mouse

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor (GDNF) family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, pheochromocytoma and parathyroid hyperplasia.

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