Frizzled-7

FZD7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Z33
Identifiers
Aliases	FZD7, FzE3, frizzled class receptor 7
External IDs	OMIM: 603410 MGI: 108570 HomoloGene: 20751 GeneCards: FZD7
Gene location (Human)
Chr.	Chromosome 2 (human)
End	202,038,441 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	59,526,114 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; germinal epithelium; ; urethra; ; lactiferous duct; ; tibia; ; parotid gland; ; cerebellar vermis; ; parietal pleura; ; seminal vesicula; ; caput epididymis;
	Top expressed in
	medullary collecting duct; ; renal corpuscle; ; ascending aorta; ; aortic valve; ; saccule; ; triceps brachii muscle; ; masseter muscle; ; belly cord; ; calvaria; ; iris;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; frizzled binding; signal transducer activity; Wnt-protein binding; protein binding; transmembrane signaling receptor activity; phosphatidylinositol-4,5-bisphosphate binding; G protein-coupled receptor activity; Wnt-activated receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; recycling endosome membrane; endosome; endosome membrane;
Biological process	negative regulation of cell-substrate adhesion; cellular response to retinoic acid; G protein-coupled receptor signaling pathway; non-canonical Wnt signaling pathway; regulation of transcription, DNA-templated; positive regulation of epithelial cell proliferation involved in wound healing; T cell differentiation in thymus; non-canonical Wnt signaling pathway via JNK cascade; negative regulation of ectodermal cell fate specification; somatic stem cell division; positive regulation of JNK cascade; Wnt signaling pathway; stem cell population maintenance; positive regulation of transcription, DNA-templated; multicellular organism development; cell surface receptor signaling pathway; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; neuron differentiation; canonical Wnt signaling pathway; substrate adhesion-dependent cell spreading; positive regulation of phosphorylation; signal transduction; mesenchymal to epithelial transition; Wnt signaling pathway, planar cell polarity pathway; negative regulation of cardiac muscle cell differentiation; regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8324
	14369
	ENSG00000155760
	ENSMUSG00000041075
	O75084
	Q61090
	NM_003507
	NM_008057
	NP_003498
	NP_032083
	Wikidata
View/Edit Human	View/Edit Mouse

Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.

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