FYB

FYB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1RI9, 2GTJ, 2GTO
Identifiers
Aliases	FYB1, ADAP, PRO0823, SLAP-130, SLAP130, FYB, FYN binding protein, THC3, FYN binding protein 1
External IDs	OMIM: 602731 MGI: 1346327 HomoloGene: 22664 GeneCards: FYB1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	39,274,528 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	6,692,794 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; lymph node; ; bone marrow cells; ; spongy bone; ; appendix; ; spleen; ; thymus; ; thymus; ; gallbladder;
	Top expressed in
	thymus; ; spleen; ; lymph node; ; spermatid; ; blood; ; morula; ; subcutaneous adipose tissue; ; spermatocyte; ; seminal vesicula; ; seminiferous tubule;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; lipid binding; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; nucleus; actin cytoskeleton; plasma membrane; cell junction;
Biological process	protein phosphorylation; intracellular signal transduction; protein localization to plasma membrane; T cell receptor signaling pathway; immune response; signal transduction; NLS-bearing protein import into nucleus; biological process; integrin-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2533
	23880
	ENSG00000082074
	ENSMUSG00000022148
	O15117
	O35601
	NM_001243093; NM_001465; NM_199335; NM_001349333; NM_018594
	NM_001278269; NM_011815
	NP_001230022; NP_001456; NP_955367; NP_001336262; NP_061064
	NP_001265198; NP_035945
	Wikidata
View/Edit Human	View/Edit Mouse

FYN binding protein (FYB-120/130), also known as FYB, ADAP (Adhesion and degranulation-promoting adapter protein), and SLAP-130 (SLP-76-associated phosphoprotein) is a protein that is encoded by the FYB gene in humans. The protein is expressed in T cells, monocytes, mast cells, macrophages, NK cells, but not B cells. FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling.

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