eIF4A
The eukaryotic initiation factor-4A (eIF4A) family consists of 3 closely related proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA.
| eukaryotic translation initiation factor 4A, isoform 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EIF4A1 | ||||||
| Alt. symbols | EIF4A | ||||||
| NCBI gene | 1973 | ||||||
| HGNC | 3282 | ||||||
| OMIM | 602641 | ||||||
| RefSeq | NM_001416 | ||||||
| UniProt | P60842 | ||||||
| Other data | |||||||
| Locus | Chr. 17 p13 | ||||||
| |||||||
| eukaryotic translation initiation factor 4A, isoform 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EIF4A2 | ||||||
| Alt. symbols | EIF4F | ||||||
| NCBI gene | 1974 | ||||||
| HGNC | 3284 | ||||||
| OMIM | 601102 | ||||||
| RefSeq | NM_001967 | ||||||
| UniProt | Q14240 | ||||||
| Other data | |||||||
| EC number | 3.6.1.1 | ||||||
| Locus | Chr. 3 q28 | ||||||
| |||||||
| eukaryotic translation initiation factor 4A, isoform 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | EIF4A3 | ||||||
| Alt. symbols | DDX48 | ||||||
| NCBI gene | 9775 | ||||||
| HGNC | 18683 | ||||||
| OMIM | 608546 | ||||||
| RefSeq | NM_014740 | ||||||
| UniProt | P38919 | ||||||
| Other data | |||||||
| Locus | Chr. 17 q25.3 | ||||||
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