EIF4A3

EIF4A3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HXY, 2HYI, 2J0Q, 2J0S, 2J0U, 2XB2, 3EX7, 4C9B
Identifiers
Aliases	EIF4A3, DDX48, MUK34, NMP265, NUK34, RCPS, eIF4AIII, eukaryotic translation initiation factor 4A3, Fal1, eIF4A-III, eIF-4A-III
External IDs	OMIM: 608546 MGI: 1923731 HomoloGene: 5602 GeneCards: EIF4A3
Gene location (Human)
Chr.	Chromosome 17 (human)
End	80,147,151 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	119,190,915 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; olfactory bulb; ; mucosa of urinary bladder; ; skin of abdomen; ; human penis; ; left adrenal gland; ; peritoneum; ; right adrenal gland; ; embryo; ; ganglionic eminence;
	Top expressed in
	morula; ; neural tube; ; thymus; ; mesencephalon; ; spleen; ; bone marrow; ; ganglionic eminence; ; lung; ; yolk sac; ; placenta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; selenocysteine insertion sequence binding; helicase activity; poly(A) binding; RNA stem-loop binding; protein binding; nucleic acid binding; ribonucleoprotein complex binding; hydrolase activity; ATP binding; mRNA binding; RNA binding; translation regulator activity;
Cellular component	cytoplasm; cytosol; nuclear speck; catalytic step 2 spliceosome; membrane; exon-exon junction complex; neuronal cell body; dendrite; spliceosomal complex; nucleus; nucleoplasm; nucleolus; glutamatergic synapse; postsynaptic cytosol; ribonucleoprotein complex; U2-type catalytic step 1 spliceosome;
Biological process	nuclear-transcribed mRNA poly(A) tail shortening; mRNA transport; negative regulation of translation; associative learning; response to organic cyclic compound; regulation of mRNA binding; mRNA processing; positive regulation of translation; negative regulation of gene expression; negative regulation of excitatory postsynaptic potential; cellular response to brain-derived neurotrophic factor stimulus; cellular response to selenite ion; exploration behavior; RNA secondary structure unwinding; RNA splicing; rRNA processing; embryonic cranial skeleton morphogenesis; negative regulation of selenocysteine insertion sequence binding; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; regulation of translation; negative regulation of selenocysteine incorporation; mRNA splicing, via spliceosome; RNA export from nucleus; termination of RNA polymerase II transcription; mRNA export from nucleus; mRNA 3'-end processing; positive regulation of transcription by RNA polymerase II; positive regulation of mRNA splicing, via spliceosome; transport; regulation of translation at postsynapse, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	9775
	192170
	ENSG00000141543
	ENSMUSG00000025580
	P38919
	Q91VC3
	NM_014740
	NM_138669
	NP_055555
	NP_619610
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic initiation factor 4A-III is a protein that in humans is encoded by the EIF4A3 gene.

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