Dimenhydrinate

Dimenhydrinate
Combination of
Diphenhydramine	Antihistamine, sedative
8-chlorotheophylline	Stimulant
Clinical data
Trade names	Dramamine, Draminate, Gravol, others
AHFS/Drugs.com	Monograph
MedlinePlus	a607046
License data	US DailyMed: Dimenhydrinate;
Pregnancy; category	AU: A;
Routes of; administration	By mouth, rectal, intravascular, intramuscular
ATC code	R06AA11 (WHO) combinations R06AA61 (WHO);
Legal status
Legal status	AU: S2 (Pharmacy medicine); CA: OTC; US: OTC;
Pharmacokinetic data
Metabolism	Liver
Elimination half-life	5.5 hours (diphenhydramine component)
Identifiers
CAS Number	523-87-5 ;
PubChem CID	10660;
DrugBank	DB00985 ;
ChemSpider	10210 ;
UNII	JB937PER5C;
KEGG	D00520 ;
ChEBI	CHEBI:94848;
ChEMBL	ChEMBL1200406 ;
CompTox Dashboard (EPA)	DTXSID9025087 ;
ECHA InfoCard	100.007.593
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Dimenhydrinate, sold under the brand name Dramamine, among others, is an over-the-counter medication used to treat motion sickness and nausea. Dimenhydrinate is a theoclate salt composed of diphenhydramine (an ethanolamine derivative) and 8-chlorotheophylline (a chlorinated theophylline derivative) in a 1:1 ratio.

Dimenhydrinate was introduced to the market by G.D. Searle in 1949.

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