DCL1

DCL1 (an abbreviation of Dicer-like 1) is a gene in plants that codes for the DCL1 protein, a ribonuclease III enzyme involved in processing double-stranded RNA (dsRNA) and microRNA (miRNA). Although DCL1, also called Endoribonuclease Dicer homolog 1, is named for its homology with the metazoan protein Dicer, its role in miRNA biogenesis is somewhat different, due to substantial differences in miRNA maturation processes between plants and animals, as well due to additional downstream plant-specific pathways, where DCL1 paralogs like DCL4 participate, such Trans-acting siRNA biogenesis.

Endoribonuclease Dicer homolog 1
Cartoon representation of Arabidopsis DCL1 in complex with pri-miRNA 166f. Single chain of DCL1 in light purple catalyzing the cleavage of pri-miRNA-166f into pre-miRNA-166f, before one more cleavage step to finally release miRNA-166f.
Identifiers
OrganismArabidopsis thaliana
SymbolDCL1
Alt. symbolsAT1G01040
PDB7ELD
UniProtQ9SP32
Other data
EC numberEC:3.1.26
Chromosome1: 0.02 - 0.03 Mb
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StructuresSwiss-model
DomainsInterPro
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