Dicer

DICER1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2EB1, 4NGB, 4NGC, 4NGD, 4NGF, 4NGG, 4NH3, 4NH5, 4NH6, 4NHA, 4WYQ
Identifiers
Aliases	DICER1, DCR1, Dicer, Dicer1e, HERNA, MNG1, RMSE2, K12H4.8-LIKE, dicer 1, ribonuclease III, GLOW
External IDs	OMIM: 606241 MGI: 2177178 HomoloGene: 13251 GeneCards: DICER1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	95,158,010 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	104,718,211 bp
RNA expression pattern
	Top expressed in
	caput epididymis; ; optic nerve; ; spongy bone; ; corpus epididymis; ; visceral pleura; ; cavity of mouth; ; parietal pleura; ; inferior ganglion of vagus nerve; ; nipple; ; corpus callosum;
	Top expressed in
	secondary oocyte; ; medullary collecting duct; ; renal corpuscle; ; abdominal wall; ; primitive streak; ; maxillary prominence; ; somite; ; superior cervical ganglion; ; ganglionic eminence; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; helicase activity; protein domain specific binding; pre-miRNA binding; metal ion binding; endoribonuclease activity; endoribonuclease activity, producing 5'-phosphomonoesters; protein binding; siRNA binding; RNA binding; nuclease activity; double-stranded RNA binding; endonuclease activity; hydrolase activity; ATP binding; ribonuclease III activity; DNA binding; deoxyribonuclease I activity;
Cellular component	cytoplasm; cytosol; RISC complex; growth cone; ARC complex; RISC-loading complex; axon; dendrite; nucleus; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome;
Biological process	neuron projection morphogenesis; RNA processing; negative regulation of transcription by RNA polymerase II; peripheral nervous system myelin formation; pre-miRNA processing; positive regulation of myelination; nerve development; RNA phosphodiester bond hydrolysis, endonucleolytic; positive regulation of Schwann cell differentiation; negative regulation of Schwann cell proliferation; production of miRNAs involved in gene silencing by miRNA; miRNA metabolic process; production of siRNA involved in RNA interference; gene silencing; apoptotic DNA fragmentation; negative regulation of tumor necrosis factor production; NIK/NF-kappaB signaling; negative regulation of gene expression; tube formation;
	Sources:Amigo / QuickGO
Orthologs
	23405
	192119
	ENSG00000100697
	ENSMUSG00000041415
	Q9UPY3
	Q8R418
	NM_001195573; NM_001271282; NM_001291628; NM_030621; NM_177438
	NM_148948
	NP_001182502; NP_001258211; NP_001278557; NP_085124; NP_803187
	NP_683750
	Wikidata
View/Edit Human	View/Edit Mouse

Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20–25 base pairs long with a two-base overhang on the 3′-end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component Argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).

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