Cyclin B
Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present). The complex of Cdk and cyclin B is called maturation promoting factor or mitosis promoting factor (MPF).
| cyclin B1 | |||||||
|---|---|---|---|---|---|---|---|
Structure of human cyclin B. | |||||||
| Identifiers | |||||||
| Symbol | CCNB1 | ||||||
| Alt. symbols | CCNB | ||||||
| NCBI gene | 891 | ||||||
| HGNC | 1579 | ||||||
| OMIM | 123836 | ||||||
| RefSeq | NM_031966 | ||||||
| UniProt | P14635 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q12 | ||||||
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| cyclin B2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNB2 | ||||||
| NCBI gene | 9133 | ||||||
| HGNC | 1580 | ||||||
| OMIM | 602755 | ||||||
| RefSeq | NM_004701 | ||||||
| UniProt | O95067 | ||||||
| Other data | |||||||
| Locus | Chr. 15 q21.3 | ||||||
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| cyclin B3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | CCNB3 | ||||||
| NCBI gene | 85417 | ||||||
| HGNC | 18709 | ||||||
| OMIM | 300456 | ||||||
| RefSeq | NM_033670 | ||||||
| UniProt | Q8WWL7 | ||||||
| Other data | |||||||
| Locus | Chr. X p11 | ||||||
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