Cyclin-dependent kinase 1

CDK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YC6, 4Y72, 5HQ0, 4YC3
Identifiers
Aliases	CDK1, CDC2, CDC28A, P34CDC2, cyclin-dependent kinase 1, cyclin dependent kinase 1
External IDs	OMIM: 116940 MGI: 88351 HomoloGene: 68203 GeneCards: CDK1
Gene location (Human)
Chr.	Chromosome 10 (human)
End	60,794,852 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	69,188,768 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; spongy bone; ; secondary oocyte; ; rectum; ; bone marrow; ; tibia; ; appendix; ; stromal cell of endometrium; ; bone marrow cells; ; cavity of mouth;
	Top expressed in
	maxillary prominence; ; morula; ; medial ganglionic eminence; ; abdominal wall; ; somite; ; otic placode; ; dermis; ; primitive streak; ; hand; ; yolk sac;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; histone kinase activity; kinase activity; Hsp70 protein binding; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; ATP binding; protein serine/threonine kinase activity; chromatin binding; cyclin binding; cyclin-dependent protein kinase activity; cyclin-dependent protein serine/threonine kinase activity; virus receptor activity;
Cellular component	centrosome; membrane; spindle; nucleoplasm; microtubule organizing center; midbody; spindle microtubule; mitochondrion; mitotic spindle; extracellular exosome; cytoskeleton; nucleus; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; cytosol; mitochondrial matrix; endoplasmic reticulum membrane; cyclin B1-CDK1 complex;
Biological process	positive regulation of protein localization to nucleus; centrosome cycle; regulation of embryonic development; response to cadmium ion; epithelial cell differentiation; response to organic cyclic compound; phosphorylation; response to copper ion; positive regulation of mitotic cell cycle; negative regulation of apoptotic process; pronuclear fusion; response to activity; regulation of Schwann cell differentiation; cell division; positive regulation of DNA replication; DNA replication; mitotic nuclear membrane disassembly; positive regulation of gene expression; positive regulation of cardiac muscle cell proliferation; chromosome condensation; G2/M transition of mitotic cell cycle; response to axon injury; peptidyl-serine phosphorylation; animal organ regeneration; response to organonitrogen compound; response to amine; DNA repair; cell cycle; anaphase-promoting complex-dependent catabolic process; microtubule cytoskeleton organization; response to ethanol; mitotic G2 DNA damage checkpoint signaling; Golgi disassembly; peptidyl-threonine phosphorylation; cell migration; ventricular cardiac muscle cell development; response to toxic substance; response to hydrogen peroxide; cellular response to hydrogen peroxide; protein localization to kinetochore; apoptotic process; cell population proliferation; proteasome-mediated ubiquitin-dependent protein catabolic process; mitotic cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; regulation of gene expression; regulation of meiotic cell cycle; ciliary basal body-plasma membrane docking; protein phosphorylation; positive regulation of G2/M transition of mitotic cell cycle; protein deubiquitination; mitotic cell cycle phase transition; positive regulation of mitochondrial ATP synthesis coupled electron transport; viral entry into host cell; regulation of G2/M transition of mitotic cell cycle; transcription initiation from RNA polymerase II promoter; protein-containing complex assembly; regulation of mitotic cell cycle phase transition; regulation of circadian rhythm;
	Sources:Amigo / QuickGO
Orthologs
	983
	12534
	ENSG00000170312
	ENSMUSG00000019942
	P06493
	P11440
NM_001130829; NM_001170406; NM_001170407; NM_001786; NM_033379;
	NM_001320918
	NM_007659
	NP_001163877; NP_001163878; NP_001307847; NP_001777; NP_203698
	NP_031685
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 1 also known as CDK1 or cell division cycle protein 2 homolog is a highly conserved protein that functions as a serine/threonine protein kinase, and is a key player in cell cycle regulation. It has been highly studied in the budding yeast S. cerevisiae, and the fission yeast S. pombe, where it is encoded by genes cdc28 and cdc2, respectively. With its cyclin partners, Cdk1 forms complexes that phosphorylate a variety of target substrates (over 75 have been identified in budding yeast); phosphorylation of these proteins leads to cell cycle progression.

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