Coagulation factor II receptor

F2R
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1NRN, 1NRO, 1NRP, 1NRQ, 1NRR, 3BEF, 3HKI, 3HKJ, 3LU9, 3VW7
Identifiers
Aliases	F2R, CHTR, PAR-1, PAR1, TR, Coagulation factor II receptor, coagulation factor II thrombin receptor
External IDs	OMIM: 187930 MGI: 101802 HomoloGene: 1510 GeneCards: F2R
Gene location (Human)
Chr.	Chromosome 5 (human)
End	76,735,770 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	95,754,995 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; ganglionic eminence; ; right lung; ; gallbladder; ; right coronary artery; ; lower lobe of lung; ; ascending aorta; ; skin of abdomen; ; minor salivary gland; ; spleen;
	Top expressed in
	molar; ; renal corpuscle; ; external carotid artery; ; internal carotid artery; ; ciliary body; ; conjunctival fornix; ; abdominal wall; ; left lung lobe; ; right lung; ; atrioventricular valve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; thrombin-activated receptor activity; G-protein beta-subunit binding; protein binding; G-protein alpha-subunit binding; signaling receptor binding;
Cellular component	integral component of membrane; platelet dense tubular network; late endosome; Golgi apparatus; postsynaptic membrane; membrane; neuromuscular junction; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; early endosome; caveola;
Biological process	negative regulation of neuron apoptotic process; positive regulation of collagen biosynthetic process; hemostasis; establishment of synaptic specificity at neuromuscular junction; release of sequestered calcium ion into cytosol; platelet dense granule organization; regulation of sensory perception of pain; thrombin-activated receptor signaling pathway; positive regulation of cell migration; positive regulation of cytosolic calcium ion concentration; anatomical structure morphogenesis; blood coagulation; positive regulation of release of sequestered calcium ion into cytosol; platelet activation; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to lipopolysaccharide; positive regulation of transcription, DNA-templated; protein kinase C-activating G protein-coupled receptor signaling pathway; positive regulation of blood coagulation; response to wounding; positive regulation of vasoconstriction; positive regulation of cell population proliferation; connective tissue replacement involved in inflammatory response wound healing; positive regulation of ERK1 and ERK2 cascade; regulation of interleukin-1 beta production; positive regulation of I-kappaB kinase/NF-kappaB signaling; homeostasis of number of cells within a tissue; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of blood coagulation; inflammatory response; negative regulation of glomerular filtration; activation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of smooth muscle contraction; positive regulation of MAPK cascade; negative regulation of cell population proliferation; negative regulation of renin secretion into blood stream; signal transduction; positive regulation of calcium ion transport; positive regulation of Rho protein signal transduction; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission; positive regulation of GTPase activity; cell-cell junction maintenance; G protein-coupled receptor signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	2149
	14062
	ENSG00000181104
	ENSMUSG00000048376
	P25116
	P30558
	NM_001992; NM_001311313
	NM_010169
	NP_001298242; NP_001983
	NP_034299
	Wikidata
View/Edit Human	View/Edit Mouse

Proteinase-activated receptor 1 (PAR1) also known as protease-activated receptor 1 or coagulation factor II (thrombin) receptor is a protein that in humans is encoded by the F2R gene. PAR1 is a G protein-coupled receptor and one of four protease-activated receptors involved in the regulation of thrombotic response. Highly expressed in platelets and endothelial cells, PAR1 plays a key role in mediating the interplay between coagulation and inflammation, which is important in the pathogenesis of inflammatory and fibrotic lung diseases. It is also involved both in disruption and maintenance of endothelial barrier integrity, through interaction with either thrombin or activated protein C, respectively.

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