Protease-activated receptor
Protease-activated receptors (PAR) are a subfamily of related G protein-coupled receptors that are activated by cleavage of part of their extracellular domain. They are highly expressed in platelets, and also on endothelial cells, fibroblasts, immune cells, myocytes, neurons, and tissues that line the gastrointestinal tract.
| coagulation factor II thrombin receptor | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | F2R | ||||||
| Alt. symbols | TR; HTR; CF2R; PAR1; PAR-1 | ||||||
| NCBI gene | 2149 | ||||||
| HGNC | 3537 | ||||||
| OMIM | 187930 | ||||||
| PDB | 3BEF | ||||||
| RefSeq | NM_001992 | ||||||
| UniProt | P25116 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q13.3 | ||||||
| |||||||
| F2R like trypsin receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | F2RL1 | ||||||
| Alt. symbols | PAR2, GPR11 | ||||||
| NCBI gene | 2150 | ||||||
| HGNC | 3538 | ||||||
| OMIM | 600933 | ||||||
| PDB | 5NDD | ||||||
| RefSeq | NM_005242 | ||||||
| UniProt | P55085 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q13.3 | ||||||
| |||||||
| coagulation factor II thrombin receptor like 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | F2RL2 | ||||||
| Alt. symbols | PAR3; PAR-3 | ||||||
| NCBI gene | 2151 | ||||||
| HGNC | 3539 | ||||||
| OMIM | 601919 | ||||||
| PDB | 2PUX | ||||||
| RefSeq | NM_004101 | ||||||
| UniProt | O00254 | ||||||
| Other data | |||||||
| Locus | Chr. 5 q13.3 | ||||||
| |||||||
| F2R like thrombin or trypsin receptor 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | F2RL3 | ||||||
| Alt. symbols | PAR4 | ||||||
| NCBI gene | 9002 | ||||||
| HGNC | 3540 | ||||||
| OMIM | 602779 | ||||||
| PDB | 2PV9 | ||||||
| RefSeq | NM_003950 | ||||||
| UniProt | Q96RI0 | ||||||
| Other data | |||||||
| Locus | Chr. 19 p13.11 | ||||||
| |||||||
Protease-activated receptors, or PARs, are not to be mistaken with PAR proteins, a group of regulators of cellular polarity named after their associated partitioning phenotype.
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