Carboplatin

Carboplatin
Clinical data
Pronunciation	/ˈkɑːrboʊˌplætən/
Trade names	Paraplatin, others
AHFS/Drugs.com	Monograph
MedlinePlus	a695017
Routes of; administration	Intravenous
ATC code	L01XA02 (WHO) ;
Legal status
Legal status	US: WARNING; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	complete
Protein binding	Very low
Elimination half-life	1.1-2 hours
Excretion	Kidney
Identifiers
	IUPAC name cis-diammine(cyclobutane-1,1-dicarboxylate-O,O')platinum(II);
CAS Number	41575-94-4 ;
PubChem CID	498142;
DrugBank	DB00958 ;
ChemSpider	8514637 ;
UNII	BG3F62OND5;
KEGG	D01363 ;
ChEBI	CHEBI:31355 ;
ChEMBL	ChEMBL288376 ;
CompTox Dashboard (EPA)	DTXSID3046742 ;
ECHA InfoCard	100.050.388
Chemical and physical data
Formula	C6H12N2O4Pt
Molar mass	371.256 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CC2(C1)C(=O)O[Pt-2]([NH3+])([NH3+])OC2=O;
	InChI InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2 ; Key:OLESAACUTLOWQZ-UHFFFAOYSA-L ;
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Carboplatin, sold under the brand name Paraplatin among others, is a chemotherapy medication used to treat a number of forms of cancer. This includes ovarian cancer, lung cancer, head and neck cancer, brain cancer, and neuroblastoma. It is used by injection into a vein.

Side effects generally occur. Common side effects include low blood cell levels, nausea, and electrolyte problems. Other serious side effects include allergic reactions and mutagenesis. It may be carcinogenic, but further research is needed to confirm this. Use during pregnancy may result in harm to the baby. Carboplatin is in the platinum-based antineoplastic family of medications and works by interfering with duplication of DNA.

Carboplatin was developed as a less toxic analogue of cisplatin. It was patented in 1972 and approved for medical use in 1989. It is on the 2023 World Health Organization's List of Essential Medicines.

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