Cytotoxic T-lymphocyte associated protein 4

CTLA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OSK, 1AH1, 1H6E, 1I85, 1I8L, 2X44, 3BX7
Identifiers
Aliases	CTLA4, ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12, cytotoxic T-lymphocyte associated protein 4
External IDs	OMIM: 123890 MGI: 88556 HomoloGene: 3820 GeneCards: CTLA4
Gene location (Human)
Chr.	Chromosome 2 (human)
End	203,873,965 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	60,954,991 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; pancreatic epithelial cell; ; pancreatic ductal cell; ; superficial temporal artery; ; gallbladder; ; thymus; ; rectum; ; spleen; ; blood;
	Top expressed in
	secondary oocyte; ; thymus; ; spleen; ; ileum; ; zone of skin; ; jejunum; ; esophagus; ; colon; ; heart; ; duodenum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	perinuclear region of cytoplasm; integral component of membrane; clathrin-coated endocytic vesicle; plasma membrane; Golgi apparatus; membrane; external side of plasma membrane; protein complex involved in cell adhesion; integral component of plasma membrane;
Biological process	B cell receptor signaling pathway; T cell costimulation; negative regulation of B cell proliferation; adaptive immune response; negative regulation of regulatory T cell differentiation; immune response; cellular response to DNA damage stimulus; immune system process; positive regulation of apoptotic process; negative regulation of immune response; negative regulation of T cell proliferation; regulation of regulatory T cell differentiation; regulation of T cell proliferation; T cell receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1493
	12477
	ENSG00000163599
	ENSMUSG00000026011
	P16410
	P09793
	NM_001037631; NM_005214
	NM_001281976; NM_009843
	NP_001032720; NP_005205
	NP_001268905; NP_033973
	Wikidata
View/Edit Human	View/Edit Mouse

Cytotoxic T-lymphocyte associated protein 4, (CTLA-4) also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA-4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. It is encoded by the gene CTLA4 in humans.

The CTLA-4 protein is encoded by the Ctla-4 gene in mice.

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