CD86

CD86
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1I85, 1NCN
Identifiers
Aliases	CD86, B7-2, B7.2, B70, CD28LG2, LAB72, CD86 molecule
External IDs	OMIM: 601020 MGI: 101773 HomoloGene: 10443 GeneCards: CD86
Gene location (Human)
Chr.	Chromosome 3 (human)
End	122,121,139 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	36,486,443 bp
RNA expression pattern
	Top expressed in
	monocyte; ; appendix; ; blood; ; lymph node; ; gallbladder; ; spleen; ; right lung; ; rectum; ; bone marrow; ; upper lobe of left lung;
	Top expressed in
	spleen; ; thymus; ; blood; ; subcutaneous adipose tissue; ; Paneth cell; ; white adipose tissue; ; dermis; ; liver; ; carotid body; ; belly cord;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	coreceptor activity; virus receptor activity; protein binding; signaling receptor binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; signaling receptor activity;
Cellular component	integral component of membrane; intracellular membrane-bounded organelle; membrane; plasma membrane; cell surface; extracellular exosome; external side of plasma membrane;
Biological process	response to yeast; adaptive immune response; response to interferon-gamma; immune system process; cell-cell signaling; T cell costimulation; human ageing; myeloid dendritic cell differentiation; cellular response to cytokine stimulus; T cell proliferation involved in immune response; toll-like receptor signaling pathway; positive regulation of transcription, DNA-templated; B cell activation; response to lipopolysaccharide; cellular response to metal ion; negative regulation of T cell anergy; defense response to virus; immune response; positive regulation of T cell proliferation; positive regulation of cell population proliferation; positive regulation of T-helper 2 cell differentiation; viral entry into host cell; viral process; toll-like receptor 3 signaling pathway; cellular response to lipopolysaccharide; T cell activation; positive regulation of activated T cell proliferation; phosphatidylinositol phosphate biosynthetic process; positive regulation of protein kinase B signaling; signal transduction; cell surface receptor signaling pathway; cytokine-mediated signaling pathway; negative regulation of T cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	942
	12524
	ENSG00000114013
	ENSMUSG00000022901
	P42081
	P42082
	NM_176892; NM_001206924; NM_001206925; NM_006889; NM_175862
	NM_019388
	NP_001193853; NP_001193854; NP_008820; NP_787058; NP_795711
	NP_062261
	Wikidata
View/Edit Human	View/Edit Mouse

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a protein constitutively expressed on dendritic cells, Langerhans cells, macrophages, B-cells (including memory B-cells), and on other antigen-presenting cells. Along with CD80, CD86 provides costimulatory signals necessary for T cell activation and survival. Depending on the ligand bound, CD86 can signal for self-regulation and cell-cell association, or for attenuation of regulation and cell-cell disassociation.

The CD86 gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.

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