CHKA

CHKA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CKO, 2CKP, 2CKQ, 2I7Q, 3F2R, 3G15, 3ZM9, 4BR3, 4CG8, 4CG9, 4CGA, 4DA5, 5AFV, 5EQE, 5EQP, 5EQY, 5FTG
Identifiers
Aliases	CHKA, CHK, CK, CKI, EK, choline kinase alpha
External IDs	OMIM: 118491 MGI: 107760 HomoloGene: 88575 GeneCards: CHKA
EC number	2.7.1.82
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,121,444 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,894,369 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; body of pancreas; ; gastric mucosa; ; body of stomach; ; Brodmann area 9; ; nucleus accumbens; ; cingulate gyrus; ; caudate nucleus; ; amygdala;
	Top expressed in
	spermatocyte; ; morula; ; medullary collecting duct; ; spermatid; ; superior frontal gyrus; ; submandibular gland; ; cerebellar cortex; ; duodenum; ; jejunum; ; lens;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein homodimerization activity; cholinesterase activity; signal transducer activity; choline binding; kinase activity; ATP binding; ethanolamine kinase activity; choline kinase activity;
Cellular component	cytoplasm; cytosol;
Biological process	lipid transport; ethanolamine metabolic process; choline metabolic process; phosphorylation; lipid metabolism; response to 3-methylcholanthrene; phospholipid biosynthetic process; response to toxic substance; CDP-choline pathway; signal transduction; phosphatidylcholine biosynthetic process; phosphatidylethanolamine biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	1119
	12660
	ENSG00000110721
	ENSMUSG00000024843
	P35790
	O54804
NM_001277; NM_212469; NM_001376219; NM_001376220; NM_001376221;
	NM_001376222
	NM_001025566; NM_001271496; NM_013490
NP_001268; NP_997634; NP_001363148; NP_001363149; NP_001363150;
	NP_001363151
	NP_001258425; NP_038518
	Wikidata
View/Edit Human	View/Edit Mouse

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene.

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.

In melanocytic cells CHKA gene expression may be regulated by MITF.

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