CDKN2D

CDKN2D
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BD8, 1BI8
Identifiers
Aliases	CDKN2D, INK4D, p19, p19-INK4D, cyclin-dependent kinase inhibitor 2D, cyclin dependent kinase inhibitor 2D
External IDs	OMIM: 600927 MGI: 105387 HomoloGene: 36081 GeneCards: CDKN2D
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,569,059 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	21,202,703 bp
RNA expression pattern
	Top expressed in
	monocyte; ; cingulate gyrus; ; prefrontal cortex; ; amygdala; ; nucleus accumbens; ; dorsolateral prefrontal cortex; ; caudate nucleus; ; blood; ; Brodmann area 9; ; putamen;
	Top expressed in
	atrium; ; thymus; ; medial ganglionic eminence; ; saccule; ; endocardial cushion; ; cingulate gyrus; ; atrioventricular valve; ; dorsomedial hypothalamic nucleus; ; mammillary body; ; ventromedial nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding;
Cellular component	cytoplasm; nucleoplasm; nucleus; cytosol; cyclin D2-CDK4 complex;
Biological process	DNA synthesis involved in DNA repair; regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to vitamin D; response to retinoic acid; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of cell growth; cell cycle; negative regulation of phosphorylation; response to UV; autophagic cell death; negative regulation of cell population proliferation; sensory perception of sound; negative regulation of cell cycle G1/S phase transition; G1/S transition of mitotic cell cycle; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of G1/S transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	1032
	12581
	ENSG00000129355
	ENSMUSG00000096472
	P55273
	Q60773
	NM_079421; NM_001800
	NM_009878
	NP_001791; NP_524145
	NP_034008
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. The expression of this gene and its protein product (p19) is observed in neurons with neurofibrillary tangles (NFTs) and it is suggested as a marker for senescent neurons. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

Note, this protein should not be confused with p19-ARF (mouse) or the human equivalent p14ARF, which are alternative products of the CDKN2A gene.

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