CDKN2A

CDKN2A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E
Identifiers
Aliases	CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF.
External IDs	OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A
Gene location (Human)
Chr.	Chromosome 9 (human)
End	21,995,301 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	89,212,890 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; pituitary gland; ; anterior pituitary; ; subthalamic nucleus; ; tongue; ; ventral tegmental area; ; superior surface of tongue; ; external globus pallidus; ; pericardium; ; inferior ganglion of vagus nerve;
	Top expressed in
	yolk sac; ; calvaria; ; Greater petrosal nerve; ; meninges; ; spermatid; ; thymus; ; adrenal gland; ; spermatocyte; ; lens; ; tracheobronchial tree;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	NF-kappaB binding; protein binding; cyclin-dependent protein serine/threonine kinase inhibitor activity; protein kinase binding; RNA binding; DNA binding; p53 binding; transcription factor binding; MDM2/MDM4 family protein binding; ubiquitin-protein transferase inhibitor activity; SUMO transferase activity; disordered domain specific binding; ubiquitin ligase inhibitor activity;
Cellular component	cytoplasm; cytosol; senescence-associated heterochromatin focus; nucleus; nuclear body; nucleoplasm; nucleolus; mitochondrion; protein-containing complex;
Biological process	positive regulation of smooth muscle cell apoptotic process; negative regulation of cyclin-dependent protein serine/threonine kinase activity; replicative senescence; G1 phase; negative regulation of cell-matrix adhesion; cellular senescence; negative regulation of cell growth; positive regulation of cellular senescence; positive regulation of macrophage apoptotic process; cell cycle; Ras protein signal transduction; negative regulation of phosphorylation; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; negative regulation of cell population proliferation; G1/S transition of mitotic cell cycle; negative regulation of G1/S transition of mitotic cell cycle; apoptotic process; regulation of G2/M transition of mitotic cell cycle; regulation of transcription, DNA-templated; regulation of protein stability; negative regulation of immature T cell proliferation in thymus; regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of proteolysis involved in cellular protein catabolic process; protein K63-linked ubiquitination; positive regulation of signal transduction by p53 class mediator; somatic stem cell division; protein stabilization; protein polyubiquitination; positive regulation of protein sumoylation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; autophagy of mitochondrion; apoptotic mitochondrial changes; regulation of protein targeting to mitochondrion; protein destabilization; negative regulation of ubiquitin-protein transferase activity; positive regulation of apoptotic process; rRNA processing; negative regulation of ubiquitin-dependent protein catabolic process; mitochondrial depolarization; positive regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of B cell proliferation; activation of cysteine-type endopeptidase activity involved in apoptotic process; regulation of apoptotic DNA fragmentation; positive regulation of transcription by RNA polymerase II; positive regulation of protein localization to nucleus; protein sumoylation; positive regulation of gene expression; negative regulation of ubiquitin protein ligase activity; amyloid fibril formation; negative regulation of protein neddylation;
	Sources:Amigo / QuickGO
Orthologs
	1029
	12578
	ENSG00000147889
	ENSMUSG00000044303
	P42771; Q8N726
	P51480; Q64364
NM_000077; NM_001195132; NM_058195; NM_058196; NM_058197;
	NM_001363763
	NM_001040654; NM_009877
NP_000068; NP_001182061; NP_478102; NP_478104; NP_001350692;
	NP_478102.2
	NP_001035744; NP_034007; NP_034007.1
	Wikidata
View/Edit Human	View/Edit Mouse

CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. It is ubiquitously expressed in many tissues and cell types. The gene codes for two proteins, including the INK4 family member p16 (or p16INK4a) and p14arf. Both act as tumor suppressors by regulating the cell cycle. p16 inhibits cyclin dependent kinases 4 and 6 (CDK4 and CDK6) and thereby activates the retinoblastoma (Rb) family of proteins, which block traversal from G1 to S-phase. p14ARF (known as p19ARF in the mouse) activates the p53 tumor suppressor. Somatic mutations of CDKN2A are common in the majority of human cancers, with estimates that CDKN2A is the second most commonly inactivated gene in cancer after p53. Germline mutations of CDKN2A are associated with familial melanoma, glioblastoma and pancreatic cancer. The CDKN2A gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.

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