CDK5RAP2

CDK5RAP2
Identifiers
Aliases	CDK5RAP2, C48, Cep215, MCPH3, CDK5 regulatory subunit associated protein 2
External IDs	OMIM: 608201 MGI: 2384875 HomoloGene: 49533 GeneCards: CDK5RAP2
Gene location (Human)
Chr.	Chromosome 9 (human)
End	120,580,170 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	70,328,680 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; right coronary artery; ; ganglionic eminence; ; gastrocnemius muscle; ; minor salivary gland; ; ascending aorta; ; Achilles tendon; ; corpus callosum; ; left coronary artery; ; tibia;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; secondary oocyte; ; adrenal gland; ; yolk sac; ; thymus; ; maxillary prominence; ; autopod region; ; hand;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule binding; tubulin binding; protein binding; protein kinase binding; calmodulin binding; gamma-tubulin binding;
Cellular component	cytoplasm; cytosol; mitotic spindle pole; centrosome; Golgi apparatus; spindle pole; pericentriolar material; microtubule organizing center; microtubule plus-end; cell junction; perinuclear region of cytoplasm; cytoskeleton; microtubule; extracellular exosome;
Biological process	regulation of neuron differentiation; negative regulation of centriole replication; neurogenesis; negative regulation of neuron differentiation; chromosome segregation; positive regulation of transcription, DNA-templated; brain development; G2/M transition of mitotic cell cycle; microtubule bundle formation; regulation of spindle checkpoint; establishment of mitotic spindle orientation; centriole replication; microtubule organizing center organization; microtubule cytoskeleton organization; ciliary basal body-plasma membrane docking; centrosome cycle; regulation of G2/M transition of mitotic cell cycle; positive regulation of microtubule polymerization; regulation of mitotic cell cycle spindle assembly checkpoint;
	Sources:Amigo / QuickGO
Orthologs
	55755
	214444
	ENSG00000136861
	ENSMUSG00000039298
	Q96SN8
	P68254; Q8K389
	NM_001011649; NM_001272039; NM_018249
	NM_145990; NM_001313762
	NP_001011649; NP_001258968; NP_060719
	NP_035869; NP_001300691; NP_666102
	Wikidata
View/Edit Human	View/Edit Mouse

CDK5 regulatory subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene. It has necessary roles in the formation and stability of microtubules from the centrosome and has been found to be linked to human brain size variation in males. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined.

CDK5RAP2 is homologous to the Drosophila protein centrosomin (cnn) and paralogous to myomegalin, which in mammals contains an Olduvai domain, a domain implicated in human brain size evolution.

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