Myomegalin

PDE4DIP
Identifiers
Aliases	PDE4DIP, CMYA2, MMGL, phosphodiesterase 4D interacting protein
External IDs	OMIM: 608117 MGI: 1891434 HomoloGene: 66961 GeneCards: PDE4DIP
Gene location (Human)
Chr.	Chromosome 1 (human)
End	149,048,286 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	97,796,023 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; Achilles tendon; ; gastric mucosa; ; popliteal artery; ; thoracic aorta; ; ascending aorta; ; tibial nerve; ; right coronary artery; ; left coronary artery; ; Brodmann area 9;
	Top expressed in
	spermatocyte; ; lip; ; spermatid; ; triceps brachii muscle; ; superior frontal gyrus; ; retinal pigment epithelium; ; pituitary gland; ; temporal muscle; ; sternocleidomastoid muscle; ; seminal vesicula;
	More reference expression data
	n/a
Gene ontology
Molecular function	enzyme binding; protein binding; molecular adaptor activity;
Cellular component	myofibril; cytoplasm; microtubule organizing center; cytoskeleton; centrosome; Golgi apparatus; nucleus; cortical microtubule plus-end;
Biological process	regulation of Golgi organization; astral microtubule organization; positive regulation of microtubule nucleation;
	Sources:Amigo / QuickGO
Orthologs
	9659
	83679
	ENSG00000178104
	ENSMUSG00000038170
	Q5VU43
	Q80YT7
NM_001002810; NM_001002811; NM_001002812; NM_001195260; NM_001195261;
	NM_001198832; NM_001198834; NM_014644; NM_022359; NM_001350520; NM_001350521; NM_001350522; NM_001350523; NM_001377392; NM_001377393
NM_001039376; NM_001110163; NM_001289701; NM_001289702; NM_031401;
	NM_177145; NM_178080
NP_001002810; NP_001002811; NP_001002812; NP_001182189; NP_001182190;
	NP_001185761; NP_001185763; NP_001337449; NP_001337450; NP_001337451; NP_001337452; NP_055459; NP_071754; NP_001364321; NP_001364322
	NP_001034465; NP_001276630; NP_001276631; NP_835181
	Wikidata
View/Edit Human	View/Edit Mouse

Myomegalin, also known as phosphodiesterase 4D-interacting protein or cardiomyopathy-associated protein 2, is a protein that in humans is encoded by the PDE4DIP gene. It has roles in the formation of microtubules from the centrosome. Its name derives from the fact that it is highly expressed in units of tubular myofibrils known as sarcomeres and is a large protein, at 2,324 amino acids. It was first characterised in 2000.

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