CLEC4M

CLEC4M
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K9J, 1SL6, 1XAR, 1XPH, 3JQH
Identifiers
Aliases	CLEC4M, CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN, C-type lectin domain family 4 member M
External IDs	OMIM: 605872 MGI: 2157942 HomoloGene: 129771 GeneCards: CLEC4M
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,769,605 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,798,984 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; germinal epithelium; ; lymph node; ; pancreatic ductal cell; ; right lung; ; placenta; ; right adrenal gland; ; upper lobe of left lung; ; appendix; ; superficial temporal artery;
	Top expressed in
	lip; ; skin of abdomen; ; spleen; ; right lung lobe; ; white adipose tissue; ; carotid body; ; esophagus; ; cervix; ; blood; ; subcutaneous adipose tissue;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; virus receptor activity; metal ion binding; calcium-dependent protein binding; mannose binding; virion binding; ICAM-3 receptor activity; carbohydrate binding; signaling receptor activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; host cell;
Biological process	leukocyte cell-cell adhesion; cell-cell recognition; intracellular transport of virus; intracellular signal transduction; antigen processing and presentation; endocytosis; adaptive immune response; immune system process; viral genome replication; peptide antigen transport; modulation by virus of host process; innate immune response; viral process; virion attachment to host cell; viral entry into host cell;
	Sources:Amigo / QuickGO
Orthologs
	10332
	170786
	ENSG00000104938
	ENSMUSG00000031494
	Q9H2X3
	Q91ZX1
NM_001144904; NM_001144905; NM_001144906; NM_001144907; NM_001144908;
	NM_001144909; NM_001144910; NM_001144911; NM_014257; NM_214675; NM_214676
	NM_133238
NP_001138376; NP_001138377; NP_001138378; NP_001138379; NP_001138380;
	NP_001138381; NP_001138382; NP_001138383; NP_055072
	NP_573501
	Wikidata
View/Edit Human	View/Edit Mouse

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299 (cluster of differentiation 299).

This gene encodes L-SIGN (liver/lymph node-specific intracellular adhesion molecules-3 grabbing non-integrin), a type II integral membrane protein that is 77% identical to CD209 antigen, an HIV gp120-binding protein. This protein, like CD209, efficiently binds both intercellular adhesion molecule 3 (ICAM3) and HIV-1 gp120, and enhances HIV-1 infection of T cells. This gene is mapped to 19p13.3, in a cluster with the CD209 and CD23/FCER2 genes. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

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