DC-SIGN

CD209
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K9I, 1SL4, 1SL5, 2B6B, 2IT5, 2IT6, 2XR5, 2XR6
Identifiers
Aliases	CD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, CD209 molecule, hDC-SIGN
External IDs	OMIM: 604672 MGI: 2157948 HomoloGene: 128353 GeneCards: CD209
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,747,564 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	3,904,309 bp
RNA expression pattern
	Top expressed in
	lymph node; ; superficial temporal artery; ; rectum; ; right coronary artery; ; jejunal mucosa; ; gallbladder; ; duodenum; ; synovial joint; ; appendix; ; subcutaneous adipose tissue;
	Top expressed in
	morula; ; skin of abdomen; ; lip; ; thymus; ; blastocyst; ; skin of back; ; white adipose tissue; ; subcutaneous adipose tissue; ; diencephalon; ; pituitary gland;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptide antigen binding; virus receptor activity; metal ion binding; protein binding; mannose binding; virion binding; carbohydrate binding;
Cellular component	cytoplasm; integral component of membrane; membrane; extracellular region; cell surface; extracellular exosome; external side of plasma membrane; host cell; plasma membrane;
Biological process	leukocyte cell-cell adhesion; cell-cell recognition; intracellular transport of virus; regulation of T cell proliferation; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; intracellular signal transduction; antigen processing and presentation; endocytosis; adaptive immune response; immune system process; viral genome replication; stimulatory C-type lectin receptor signaling pathway; peptide antigen transport; cell adhesion; modulation by virus of host process; viral entry into host cell; viral process; virion attachment to host cell; innate immune response; positive regulation of T cell proliferation; B cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	30835
	170780
	ENSG00000090659
	ENSMUSG00000040197
	Q9NNX6
	Q91ZW7
NM_001144893; NM_001144894; NM_001144895; NM_001144896; NM_001144897;
	NM_001144899; NM_021155
	NM_130905
NP_001138365; NP_001138366; NP_001138367; NP_001138368; NP_001138369;
	NP_001138371; NP_066978
	NP_570975
	Wikidata
View/Edit Human	View/Edit Mouse

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene.

DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens.

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