CD200

CD200
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BFI
Identifiers
Aliases	CD200, CD200 molecule, MOX1, MOX2, MRC, OX-2, CD-200
External IDs	OMIM: 155970 MGI: 1196990 HomoloGene: 4344 GeneCards: CD200
Gene location (Human)
Chr.	Chromosome 3 (human)
End	112,362,812 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	45,229,416 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; ganglionic eminence; ; Brodmann area 10; ; middle frontal gyrus; ; hypothalamus; ; orbitofrontal cortex; ; Brodmann area 9; ; parietal pleura; ; Brodmann area 46; ; Brodmann area 23;
	Top expressed in
	ascending aorta; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; suprachiasmatic nucleus; ; body of femur; ; arcuate nucleus; ; aortic valve; ; median eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; protein homodimerization activity; cell adhesion molecule binding; protein binding involved in heterotypic cell-cell adhesion; glycosylated region protein binding;
Cellular component	integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; cell surface; axon; neuron projection; neuronal cell body; cell body;
Biological process	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; cell recognition; homophilic cell adhesion via plasma membrane adhesion molecules; negative regulation of macrophage activation; regulation of immune response; negative regulation of leukocyte activation; negative regulation of cell population proliferation; negative regulation of NF-kappaB transcription factor activity; positive regulation of CREB transcription factor activity; heterotypic cell-cell adhesion; positive regulation of transforming growth factor beta production; cell-cell adhesion; positive regulation of arginase activity; positive regulation of protein-glutamine gamma-glutamyltransferase activity; regulation of neuroinflammatory response; negative regulation of neuroinflammatory response; negative regulation of neuron death; negative regulation of matrix metallopeptidase secretion; negative regulation of macrophage migration; negative regulation of T cell migration;
	Sources:Amigo / QuickGO
Orthologs
	4345
	17470
	ENSG00000091972
	ENSMUSG00000022661
	P41217
	O54901
NM_001004196; NM_001004197; NM_005944; NM_001318826; NM_001318828;
	NM_001318830; NM_001365851; NM_001365852; NM_001365853; NM_001365854; NM_001365855
	NM_010818; NM_001358443
NP_001004196; NP_001305755; NP_001305757; NP_001305759; NP_005935;
	NP_001352780; NP_001352781; NP_001352782; NP_001352783; NP_001352784
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) is a human protein encoded by the CD200 gene. CD200 gene is in human located on chromosome 3 in proximity to genes encoding other B7 proteins CD80/CD86. In mice CD200 gene is on chromosome 16.

The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two IgSF immunoglobulin domains, transmembrane region and a 19 amino acid long cytoplasmatic domain. CD 200 belongs to the immunoglobulin superfamily, particularly belongs to the B7 receptor family.

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