CXCR5

CXCR5
Identifiers
Aliases	CXCR5, BLR1, CD185, MDR15, C-X-C motif chemokine receptor 5, C-X-C chemokine receptor type 5
External IDs	OMIM: 601613 MGI: 103567 HomoloGene: 1298 GeneCards: CXCR5
Gene location (Human)
Chr.	Chromosome 11 (human)
End	118,897,787 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,473,174 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; appendix; ; blood; ; ascending aorta; ; left coronary artery; ; stromal cell of endometrium; ; skin of abdomen; ; canal of the cervix; ; ganglionic eminence;
	Top expressed in
	spleen; ; spermatid; ; blood; ; subcutaneous adipose tissue; ; spermatocyte; ; left lung; ; thymus; ; right lung lobe; ; white adipose tissue; ; meninges;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	C-X-C chemokine receptor activity; G protein-coupled receptor activity; protein binding; signal transducer activity; C-C chemokine receptor activity; chemokine binding; C-C chemokine binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane; external side of plasma membrane;
Biological process	positive regulation of cytokinesis; chemokine-mediated signaling pathway; chemotaxis; B cell activation; G protein-coupled receptor signaling pathway; lymph node development; immune response; signal transduction; leukocyte chemotaxis; positive regulation of cytosolic calcium ion concentration; calcium-mediated signaling; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	643
	12145
	ENSG00000160683
	ENSMUSG00000047880
	P32302
	Q04683
	NM_032966; NM_001716
	NM_007551
	NP_001707; NP_116743
	NP_031577
	Wikidata
View/Edit Human	View/Edit Mouse

C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 (BLR1) is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine receptor family. It enables T cells to migrate to lymph node and the B cell zones. In humans, the CXC-R5 protein is encoded by the CXCR5 gene.

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