P-selectin glycoprotein ligand-1

SELPLG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1G1S
Identifiers
Aliases	SELPLG, CD162, CLA, PSGL-1, PSGL1, selectin P ligand
External IDs	OMIM: 600738 MGI: 106689 HomoloGene: 2261 GeneCards: SELPLG
Gene location (Human)
Chr.	Chromosome 12 (human)
End	108,633,894 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	113,970,705 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; spleen; ; lymph node; ; inferior ganglion of vagus nerve; ; periodontal fiber; ; appendix; ; bone marrow cells; ; vena cava; ; right lung;
	Top expressed in
	thymus; ; bone marrow; ; spleen; ; blood; ; ankle joint; ; entorhinal cortex; ; superior frontal gyrus; ; subcutaneous adipose tissue; ; right lung lobe; ; substantia nigra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	signaling receptor binding; protein binding; virus receptor activity;
Cellular component	uropod; integral component of plasma membrane; integral component of membrane; membrane; plasma membrane; plasma membrane raft;
Biological process	cellular response to interleukin-6; leukocyte adhesive activation; viral entry into host cell; viral process; cell adhesion; leukocyte migration; leukocyte tethering or rolling;
	Sources:Amigo / QuickGO
Orthologs
	6404
	20345
	ENSG00000110876
	ENSMUSG00000048163
	Q14242
	Q62170
	NM_001206609; NM_003006
	NM_009151
	NP_001193538; NP_002997
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Selectin P ligand, also known as SELPLG or CD162 (cluster of differentiation 162), is a human gene.

SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin.

The organization of the SELPLG gene closely resembles that of CD43 and the human platelet glycoprotein GpIb-alpha both of which have an intron in the 5-prime-noncoding region, a long second exon containing the complete coding region, and TATA-less promoters.

P-selectin glycoprotein ligand-1 (PSGL-1) is a glycoprotein found on white blood cells and endothelial cells that binds to P-selectin (P stands for platelet), which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of the broader family of cell adhesion molecules. PSGL-1 can bind to all three members of the family but binds best (with the highest affinity) to P-selectin.

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