CD43

SPN
Identifiers
Aliases	SPN, CD43, GALGP, GPL115, LSN, sialophorin, LEU-22
External IDs	OMIM: 182160 MGI: 98384 HomoloGene: 36108 GeneCards: SPN
Gene location (Human)
Chr.	Chromosome 16 (human)
End	29,670,876 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,736,995 bp
RNA expression pattern
	Top expressed in
	monocyte; ; sperm; ; pancreatic ductal cell; ; bone marrow cells; ; vena cava; ; triceps brachii muscle; ; internal globus pallidus; ; ventral tegmental area; ; external globus pallidus; ; subthalamic nucleus;
	Top expressed in
	blood; ; thymus; ; lymph node; ; spleen; ; body of femur; ; submandibular gland; ; subcutaneous adipose tissue; ; paraventricular nucleus of hypothalamus; ; lateral geniculate nucleus; ; globus pallidus;
	More reference expression data
	n/a
Gene ontology
Molecular function	transmembrane signaling receptor activity; Hsp70 protein binding; heat shock protein binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; basement membrane; cell surface; uropod; extracellular exosome; external side of plasma membrane; extracellular space;
Biological process	negative regulation of cell adhesion; positive regulation of protein phosphorylation; negative regulation of type IV hypersensitivity; response to protozoan; T cell costimulation; negative thymic T cell selection; chemotaxis; establishment or maintenance of cell polarity; cellular defense response; cell surface receptor signaling pathway; negative regulation of T cell proliferation; defense response to bacterium; immune response; positive regulation of T cell proliferation; regulation of immune response; apoptotic signaling pathway; regulation of defense response to virus; negative regulation of T cell activation; leukocyte migration; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	6693
	20737
	ENSG00000197471
	ENSMUSG00000051457
	P16150
	P15702
	NM_001030288; NM_003123
	NM_001037810; NM_009259
	NP_001025459; NP_003114
	NP_001032899; NP_033285
	Wikidata
View/Edit Human	View/Edit Mouse

Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in humans is encoded by the SPN (sialophorin) gene.

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