Syndecan 1

SDC1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GVC, 4GVD
Identifiers
Aliases	SDC1, CD138, SDC, SYND1, syndecan, syndecan 1
External IDs	OMIM: 186355 MGI: 1349162 HomoloGene: 2252 GeneCards: SDC1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	20,225,433 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	8,843,715 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; right lobe of liver; ; skin of limb; ; gums; ; vulva; ; hair follicle; ; human penis; ; cervix epithelium; ; nipple; ; cavity of mouth;
	Top expressed in
	cumulus cell; ; molar; ; conjunctival fornix; ; skin of abdomen; ; lip; ; hair follicle; ; external carotid artery; ; condyle; ; internal carotid artery; ; cervix;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein C-terminus binding; protein binding; identical protein binding;
Cellular component	lysosomal lumen; extracellular exosome; extracellular region; integral component of membrane; Golgi lumen; integral component of plasma membrane; membrane; cell surface; plasma membrane; external side of plasma membrane; protein-containing complex;
Biological process	glycosaminoglycan catabolic process; canonical Wnt signaling pathway; wound healing; response to calcium ion; odontogenesis; glycosaminoglycan biosynthetic process; ureteric bud development; response to cAMP; positive regulation of exosomal secretion; Sertoli cell development; striated muscle cell development; positive regulation of extracellular exosome assembly; retinoid metabolic process; response to glucocorticoid; response to toxic substance; response to organic substance; response to hydrogen peroxide; glycosaminoglycan metabolic process; inflammatory response; myoblast development; leukocyte migration; cell migration; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6382
	20969
	ENSG00000115884
	ENSMUSG00000020592
	P18827
	P18828
	NM_001006946; NM_002997
	NM_011519
	NP_001006947; NP_002988
	NP_035649
	Wikidata
View/Edit Human	View/Edit Mouse

Syndecan 1 is a protein which in humans is encoded by the SDC1 gene. The protein is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Syndecan-1 is a sponge for growth factors and chemokines, with binding largely via heparan sulfate chains. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein.

Altered syndecan-1 expression has been detected in several different tumor types. Syndecan 1 can be a marker for plasma cells.

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