Common gamma chain

IL2RG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B5I, 2ERJ, 3BPL, 3QAZ, 3QB7, 4GS7
Identifiers
Aliases	IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
External IDs	OMIM: 308380 MGI: 96551 HomoloGene: 172 GeneCards: IL2RG
Gene location (Human)
Chr.	X chromosome (human)
End	71,112,108 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	100,311,861 bp
RNA expression pattern
	Top expressed in
	lymph node; ; appendix; ; rectum; ; thymus; ; spleen; ; bone marrow cells; ; blood; ; jejunal mucosa; ; monocyte; ; gallbladder;
	Top expressed in
	thymus; ; spleen; ; blood; ; right lung; ; right lung lobe; ; subcutaneous adipose tissue; ; left lung; ; bone marrow; ; external carotid artery; ; yolk sac;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	interleukin-7 receptor activity; interleukin-2 receptor activity; protein binding; cytokine receptor activity; interleukin-4 receptor activity; interleukin-2 binding; cytokine binding; interleukin-15 receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; external side of plasma membrane; endosome; cytosol; cell surface; receptor complex;
Biological process	MAPK cascade; immune response; viral process; signal transduction; interleukin-2-mediated signaling pathway; interleukin-4-mediated signaling pathway; interleukin-7-mediated signaling pathway; interleukin-15-mediated signaling pathway; interleukin-9-mediated signaling pathway; regulation of molecular function; cytokine-mediated signaling pathway; interleukin-21-mediated signaling pathway; positive regulation of phagocytosis;
	Sources:Amigo / QuickGO
Orthologs
	3561
	16186
	ENSG00000147168
	ENSMUSG00000031304
	P31785
	P34902
	NM_000206
	NM_013563; NM_001308535
	NP_000197
	NP_001295464; NP_038591
	Wikidata
View/Edit Human	View/Edit Mouse

The common gamma chain (γ_c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15 and interleukin-21 receptor. The γ_c glycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals.

This protein is located on the surface of immature blood-forming cells in bone marrow. One end of the protein resides outside the cell where it binds to cytokines and the other end of the protein resides in the interior of the cell where it transmits signals to the cell's nucleus. The common gamma chain partners with other proteins to direct blood-forming cells to form lymphocytes (a type of white blood cell). The receptor also directs the growth and maturation of lymphocyte subtypes: T cells, B cells, and natural killer cells. These cells kill viruses, make antibodies, and help regulate the entire immune system.

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