Granulocyte-macrophage colony-stimulating factor receptor

CSF2RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4NKQ, 4RS1
Identifiers
Aliases	CSF2RA, CD116, CDw116, CSF2R, CSF2RAX, CSF2RAY, CSF2RX, CSF2RY, GM-CSF-R-alpha, GMCSFR, GMR, SMDP4, colony stimulating factor 2 receptor alpha subunit, alphaGMR, colony stimulating factor 2 receptor subunit alpha, GMR-alpha, GMCSFR-alpha, granulocyte-macrophage colony-stimulating factor receptor
External IDs	OMIM: 425000, 306250 MGI: 1339754 HomoloGene: 48406 GeneCards: CSF2RA
Gene location (Human)
Chr.	X chromosome (human)
End	1,310,381 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	61,228,429 bp
RNA expression pattern
	Top expressed in
	monocyte; ; blood; ; placenta; ; sural nerve; ; right lung; ; upper lobe of left lung; ; appendix; ; gallbladder; ; bone marrow; ; bone marrow cells;
	Top expressed in
	superior frontal gyrus; ; blood; ; subcutaneous adipose tissue; ; spleen; ; substantia nigra; ; neural tube; ; lens; ; white adipose tissue; ; adrenal gland; ; islet of Langerhans;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; cytokine receptor activity; protein tyrosine kinase activity; signaling receptor activity; cytokine binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; intracellular anatomical structure; external side of plasma membrane; receptor complex;
Biological process	MAPK cascade; peptidyl-tyrosine phosphorylation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	1438
	12982
	ENSG00000198223
	ENSMUSG00000059326
	P15509
	Q00941
NM_001161529; NM_001161530; NM_001161531; NM_001161532; NM_006140;
	NM_172245; NM_172246; NM_172247; NM_172248; NM_172249; NM_001379153; NM_001379154; NM_001379155; NM_001379156; NM_001379158; NM_001379159; NM_001379160; NM_001379161; NM_001379162; NM_001379163; NM_001379164; NM_001379165; NM_001379166; NM_001379167; NM_001379168; NM_001379169
	NM_009970
NP_001155001; NP_001155002; NP_001155003; NP_001155004; NP_006131;
	NP_758448; NP_758449; NP_758450; NP_758452; NP_001366082; NP_001366083; NP_001366084; NP_001366085; NP_001366087; NP_001366088; NP_001366089; NP_001366090; NP_001366091; NP_001366092; NP_001366093; NP_001366094; NP_001366095; NP_001366096; NP_001366097; NP_001366098
	NP_034100
	Wikidata
View/Edit Human	View/Edit Mouse

The granulocyte-macrophage colony-stimulating factor receptor, also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells. In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development.

It is associated with Surfactant metabolism dysfunction type 4.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.