LAMP1

LAMP1
Identifiers
Aliases	LAMP1, CD107a, LAMPA, LGP120, lysosomal associated membrane protein 1
External IDs	OMIM: 153330 MGI: 96745 HomoloGene: 4061 GeneCards: LAMP1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	113,323,672 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	13,225,338 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; visceral pleura; ; parotid gland; ; inferior olivary nucleus; ; glomerulus; ; kidney tubule; ; metanephric glomerulus; ; pancreatic ductal cell; ; germinal epithelium; ; internal globus pallidus;
	Top expressed in
	calvaria; ; spermatocyte; ; sciatic nerve; ; molar; ; carotid body; ; proximal tubule; ; utricle; ; parotid gland; ; right lung; ; lacrimal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; virus receptor activity; protein binding; enzyme binding;
Cellular component	integral component of membrane; multivesicular body; phagolysosome membrane; vesicle; endosome; late endosome; membrane; synaptic vesicle; cytolytic granule; melanosome; integral component of plasma membrane; alveolar lamellar body; cell surface; lysosomal membrane; neuronal cell body; vacuole; dendrite; phagocytic vesicle; perinuclear region of cytoplasm; sarcolemma; lysosome; endosome membrane; extracellular exosome; cytoplasmic vesicle; external side of plasma membrane; cytosol; cytoplasm; plasma membrane; azurophil granule membrane; autolysosome; ficolin-1-rich granule membrane; integral component of synaptic vesicle membrane; late endosome membrane;
Biological process	protein stabilization; Golgi to lysosome transport; positive regulation of natural killer cell degranulation; regulation of organelle transport along microtubule; viral entry into host cell; viral process; establishment of protein localization to organelle; positive regulation of natural killer cell mediated cytotoxicity; granzyme-mediated apoptotic signaling pathway; autophagic cell death; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	3916
	16783
	ENSG00000185896
	ENSMUSG00000031447
	P11279
	P11438
	NM_005561
	NM_010684; NM_001317353
	NP_005552
	NP_001304282; NP_034814
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster of Differentiation 107a), is a protein that in humans is encoded by the LAMP1 gene. The human LAMP1 gene is located on the long arm (q) of chromosome 13 at region 3, band 4 (13q34).

Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. The LAMP-1 glycoprotein is a type I transmembrane protein which is expressed at high or medium levels in at least 76 different normal tissue cell types. It resides primarily across lysosomal membranes, and functions to provide selectins with carbohydrate ligands. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells, and may also play a role in tumor cell differentiation and metastasis.

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