Hepatocyte growth factor receptor

MET
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FYR, 1R0P, 1R1W, 1SHY, 1SSL, 2G15, 2RFN, 2RFS, 2UZX, 2UZY, 2WD1, 2WGJ, 2WKM, 3A4P, 3BUX, 3C1X, 3CCN, 3CD8, 3CE3, 3CTH, 3CTJ, 3DKC, 3DKF, 3DKG, 3EFJ, 3EFK, 3F66, 3F82, 3I5N, 3L8V, 3LQ8, 3Q6U, 3Q6W, 3QTI, 3R7O, 3RHK, 3U6H, 3U6I, 3VW8, 3ZBX, 3ZC5, 3ZCL, 3ZXZ, 3ZZE, 4AOI, 4AP7, 4DEG, 4DEH, 4DEI, 4EEV, 4GG7, 4IWD, 4K3J, 4KNB, 4MXC, 4O3T, 4O3U, 4R1V, 4R1Y, 4XMO, 4XYF, 5EYC, 5EYD
Identifiers
Aliases	MET, MET proto-oncogene, receptor tyrosine kinase, AUTS9, HGFR, RCCP2, c-Met, DFNB97, OSFD, c-met
External IDs	OMIM: 164860 MGI: 96969 HomoloGene: 206 GeneCards: MET
Gene location (Human)
Chr.	Chromosome 7 (human)
End	116,798,377 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	17,573,979 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; germinal epithelium; ; parietal pleura; ; Achilles tendon; ; middle temporal gyrus; ; bronchial epithelial cell; ; visceral pleura; ; kidney tubule; ; pancreatic ductal cell; ; placenta;
	Top expressed in
	retinal pigment epithelium; ; iris; ; conjunctival fornix; ; ciliary body; ; left lobe of liver; ; left lung lobe; ; urothelium; ; lacrimal gland; ; Paneth cell; ; medullary collecting duct;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; hepatocyte growth factor-activated receptor activity; kinase activity; protein binding; transmembrane receptor protein tyrosine kinase activity; protein tyrosine kinase activity; protein phosphatase binding; ATP binding; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; identical protein binding; Wnt-protein binding; semaphorin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; extracellular region; cell surface; basal plasma membrane; intracellular anatomical structure; receptor complex;
Biological process	negative regulation of hydrogen peroxide-mediated programmed cell death; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of endothelial cell chemotaxis; endothelial cell morphogenesis; protein phosphorylation; cell surface receptor signaling pathway; positive chemotaxis; cell population proliferation; negative regulation of autophagy; branching morphogenesis of an epithelial tube; semaphorin-plexin signaling pathway; signal transduction; positive regulation of transcription by RNA polymerase II; peptidyl-tyrosine phosphorylation; hepatocyte growth factor receptor signaling pathway; MAPK cascade; entry of bacterium into host cell; phosphatidylinositol phosphate biosynthetic process; positive regulation of microtubule polymerization; negative regulation of Rho protein signal transduction; negative regulation of stress fiber assembly; establishment of skin barrier; negative regulation of thrombin-activated receptor signaling pathway; negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of protein kinase B signaling; liver development; phagocytosis; nervous system development; Wnt signaling pathway; cell migration; neuron differentiation; pancreas development;
	Sources:Amigo / QuickGO
Orthologs
	4233
	17295
	ENSG00000105976
	ENSMUSG00000009376
	P08581
	P16056
	NM_000245; NM_001127500; NM_001324401; NM_001324402
	NM_008591
	NP_000236; NP_001120972; NP_001311330; NP_001311331
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor.

HGF receptor is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the HGF receptor. MET is normally expressed by cells of epithelial origin, while expression of HGF/SF is restricted to cells of mesenchymal origin. When HGF/SF binds its cognate receptor MET it induces its dimerization through a not yet completely understood mechanism leading to its activation.

Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body. Both the overexpression of Met/HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ligand, have been implicated in oncogenesis.

Various mutations in the MET gene are associated with papillary renal carcinoma.

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