Hepatocyte growth factor

HGF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J, 4O3T, 4O3U, 5COE, 5CP9, 5CS1, 5CS3, 5CS5, 5CS9, 5CSQ, 5CT1, 5CT2, 5CT3, 4D3C
Identifiers
Aliases	HGF, DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor
External IDs	OMIM: 142409 MGI: 96079 HomoloGene: 503 GeneCards: HGF
Gene location (Human)
Chr.	Chromosome 7 (human)
End	81,770,438 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	16,825,150 bp
RNA expression pattern
	Top expressed in
	placenta; ; stromal cell of endometrium; ; visceral pleura; ; monocyte; ; pancreatic epithelial cell; ; gallbladder; ; liver; ; right coronary artery; ; right lobe of liver; ; upper lobe of left lung;
	Top expressed in
	urethra; ; stria vascularis; ; pineal gland; ; abdominal wall; ; right lung lobe; ; liver; ; tongue; ; superior frontal gyrus; ; yolk sac; ; uterus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; identical protein binding; chemoattractant activity; protein heterodimerization activity; growth factor activity; serine-type endopeptidase activity; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
Cellular component	membrane; extracellular region; platelet alpha granule lumen; extracellular space;
Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of hydrogen peroxide-mediated programmed cell death; positive regulation of neuron projection regeneration; positive regulation of interleukin-10 production; positive regulation of cell migration; cellular response to hepatocyte growth factor stimulus; negative regulation of release of cytochrome c from mitochondria; negative regulation of interleukin-6 production; platelet degranulation; negative regulation of apoptotic process; regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; positive regulation of angiogenesis; positive regulation of myelination; positive regulation of osteoblast differentiation; myoblast proliferation; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; animal organ regeneration; cell morphogenesis; positive regulation of cell population proliferation; hyaluronan metabolic process; positive regulation of DNA biosynthetic process; negative regulation of peptidyl-serine phosphorylation; epithelial to mesenchymal transition; positive regulation of peptidyl-tyrosine phosphorylation; cell chemotaxis; liver development; positive regulation of phosphatidylinositol 3-kinase signaling; regulation of p38MAPK cascade; cell population proliferation; negative regulation of autophagy; hepatocyte growth factor receptor signaling pathway; negative regulation of inflammatory response; positive regulation of transcription by RNA polymerase II; regulation of tau-protein kinase activity; proteolysis; positive chemotaxis; MAPK cascade; peptidyl-tyrosine phosphorylation; phosphatidylinositol phosphate biosynthetic process; mitotic cell cycle; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; cytokine-mediated signaling pathway; epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologs
	3082
	15234
	ENSG00000019991
	ENSMUSG00000028864
	P14210
	Q08048
	NM_000601; NM_001010931; NM_001010932; NM_001010933; NM_001010934
	NM_010427; NM_001289458; NM_001289459; NM_001289460; NM_001289461
	NP_000592; NP_001010931; NP_001010932; NP_001010933; NP_001010934
	NP_001276387; NP_001276388; NP_001276389; NP_001276390; NP_034557
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration, and in wound healing.

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