Aryl hydrocarbon receptor nuclear translocator

ARNT
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PKY, 1X0O, 2A24, 2B02, 2HV1, 2K7S, 3F1N, 3F1O, 3F1P, 3H7W, 3H82, 4EQ1, 4GHI, 4GS9, 4H6J, 4LPZ, 4XT2
Identifiers
Aliases	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2, aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor nuclear translocator
External IDs	OMIM: 126110 MGI: 88071 HomoloGene: 1261 GeneCards: ARNT
Gene location (Human)
Chr.	Chromosome 1 (human)
End	150,876,708 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	95,404,551 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; canal of the cervix; ; gastric mucosa; ; stromal cell of endometrium; ; monocyte; ; right coronary artery; ; popliteal artery; ; right lung; ; left coronary artery;
	Top expressed in
	ascending aorta; ; aortic valve; ; parotid gland; ; tongue; ; cumulus cell; ; molar; ; atrium; ; pineal gland; ; external carotid artery; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; protein dimerization activity; DNA-binding transcription factor activity; transcription coactivator activity; aryl hydrocarbon receptor binding; transcription factor binding; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein homodimerization activity; sequence-specific double-stranded DNA binding; nuclear receptor activity;
Cellular component	cytoplasm; transcription regulator complex; nucleoplasm; RNA polymerase II transcription regulator complex; nucleus; nuclear body;
Biological process	positive regulation of vascular endothelial growth factor receptor signaling pathway; cell differentiation; response to hypoxia; regulation of transcription, DNA-templated; positive regulation of endothelial cell proliferation; regulation of transcription from RNA polymerase II promoter in response to oxidative stress; positive regulation of erythrocyte differentiation; embryonic placenta development; mRNA transcription by RNA polymerase II; positive regulation of protein sumoylation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; intracellular receptor signaling pathway; regulation of transcription from RNA polymerase II promoter in response to hypoxia; positive regulation of vascular endothelial growth factor production; positive regulation of glycolytic process; positive regulation of transcription by RNA polymerase II; positive regulation of hormone biosynthetic process; xenobiotic metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	405
	11863
	ENSG00000143437
	ENSMUSG00000015522
	P27540
	P53762
NM_001197325; NM_001286035; NM_001286036; NM_001668; NM_178426;
	NM_178427; NM_001350224; NM_001350225; NM_001350226
	NM_001037737; NM_009709
NP_001184254; NP_001272964; NP_001272965; NP_001659; NP_848514;
	NP_001337153; NP_001337154; NP_001337155
	NP_001032826; NP_033839
	Wikidata
View/Edit Human	View/Edit Mouse

The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL–ARNT fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

The aryl hydrocarbon receptor (AhR) is involved in the induction of several enzymes that participate in xenobiotic metabolism. The ligand-free, cytosolic form of the aryl hydrocarbon receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only into the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound AhR to xenobiotic responsive elements in the promoters of genes for these enzymes.

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