UBA protein domain
Ubiquitin-associated (UBA) domains are protein domains that non-covalently interact with ubiquitin through protein-protein interactions. Ubiquitin is a small protein that is covalently linked to other proteins as part of intracellular signaling pathways, often as a signal for protein degradation. UBA domains are among the most common ubiquitin-binding domains.
| UBA | |||||||||
|---|---|---|---|---|---|---|---|---|---|
The NMR structure of a UBA domain from the protein ubiquilin-1 (top, cyan) bound to ubiquitin (bottom, orange), illustrating the three-helix bundle structure of the UBA domain. Isoleucine 44, the center of a hydrophobic patch on the ubiquitin surface that interacts with a number of ubiquitin-binding domains, is highlighted in blue. Rendered from PDB: 2JY6. | |||||||||
| Identifiers | |||||||||
| Symbol | UBA | ||||||||
| Pfam | PF00627 | ||||||||
| Pfam clan | CL0214 | ||||||||
| InterPro | IPR015940 | ||||||||
| PROSITE | PDOC50030 | ||||||||
| SCOP2 | 1efu / SCOPe / SUPFAM | ||||||||
| CDD | cd00194 | ||||||||
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