BCL6

BCL6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1R28, 1R29, 1R2B, 2EN2, 2EOS, 2LCE, 2YRM, 3BIM, 3E4U, 3LBZ, 4CP3, 4U2M
Identifiers
Aliases	BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51, B-cell CLL/lymphoma 6, B cell CLL/lymphoma 6, transcription repressor, BCL6 transcription repressor
External IDs	OMIM: 109565 MGI: 107187 HomoloGene: 7640 GeneCards: BCL6
Gene location (Human)
Chr.	Chromosome 3 (human)
End	187,745,725 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	23,807,602 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; gastric mucosa; ; blood; ; left uterine tube; ; pericardium; ; right lung; ; bronchial epithelial cell; ; skin of abdomen; ; tibial nerve; ; deltoid muscle;
	Top expressed in
	facial motor nucleus; ; extensor digitorum longus muscle; ; masseter muscle; ; intercostal muscle; ; triceps brachii muscle; ; ciliary body; ; ankle; ; plantaris muscle; ; motor neuron; ; vastus lateralis muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity; intronic transcription regulatory region sequence-specific DNA binding; chromatin binding; metal ion binding; protein binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; nucleic acid binding; chromatin DNA binding; identical protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	replication fork; nucleus; nucleoplasm; Golgi apparatus;
Biological process	regulation of germinal center formation; positive regulation of histone deacetylation; negative regulation of T-helper 2 cell differentiation; protein localization; negative regulation of mast cell cytokine production; regulation of transcription, DNA-templated; immune system process; regulation of GTPase activity; regulation of transcription by RNA polymerase II; negative regulation of cell differentiation; germinal center formation; negative regulation of Rho protein signal transduction; negative regulation of isotype switching to IgE isotypes; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; type 2 immune response; cellular response to DNA damage stimulus; negative regulation of cell-matrix adhesion; regulation of cell population proliferation; positive regulation of B cell proliferation; negative regulation of cell growth; Rho protein signal transduction; cell morphogenesis; spermatogenesis; regulation of memory T cell differentiation; positive regulation of neuron differentiation; regulation of inflammatory response; regulation of immune response; positive regulation of apoptotic process; negative regulation of type 2 immune response; negative regulation of B cell apoptotic process; B cell differentiation; inflammatory response; negative regulation of transcription, DNA-templated; actin cytoskeleton organization; negative regulation of cell population proliferation; negative regulation of Notch signaling pathway; erythrocyte development; negative regulation of cellular senescence; regulation of apoptotic process; negative regulation of mitotic cell cycle DNA replication; positive regulation of regulatory T cell differentiation; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	604
	12053
	ENSG00000113916
	ENSMUSG00000022508
	P41182
	P41183
	NM_001130845; NM_001134738; NM_001706; NM_138931
	NM_009744; NM_001348026
	NP_001124317; NP_001128210; NP_001697
	NP_001334955; NP_033874
	Wikidata
View/Edit Human	View/Edit Mouse

Bcl-6 (B-cell lymphoma 6) is a protein that in humans is encoded by the BCL6 gene. BCL6 is a master transcription factor for regulation of T follicular helper cells (T_FH cells) proliferation. BCL6 has three evolutionary conserved structural domains. The interaction of these domains with corepressors allows for germinal center development and leads to B cell proliferation.

The deletion of BCL6 is known to lead to failure of germinal center formation in the follicles of the lymph nodes, preventing B cells from undergoing somatic hypermutation. Mutations in BCL6 can lead to B cell lymphomas because it promotes unchecked B cell growth. Clinically, BCL6 can be used to diagnose B cell lymphomas and is shown to be upregulated in a number of cancers.

Other BCL genes, including BCL2, BCL3, BCL5, BCL7A, BCL9, and BCL10, also have clinical significance in lymphoma.

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