BCL10

BCL10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2MB9
Identifiers
Aliases	BCL10, CARMEN, CIPER, CLAP, c-E10, mE10, IMD37, B-cell CLL/lymphoma 10, B cell CLL/lymphoma 10, immune signaling adaptor, BCL10 immune signaling adaptor
External IDs	OMIM: 603517 MGI: 1337994 HomoloGene: 2912 GeneCards: BCL10
Gene location (Human)
Chr.	Chromosome 1 (human)
End	85,276,632 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	145,640,111 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; palpebral conjunctiva; ; germinal epithelium; ; amniotic fluid; ; tibia; ; jejunal mucosa; ; cavity of mouth; ; visceral pleura; ; endothelial cell;
	Top expressed in
	saccule; ; otic placode; ; Paneth cell; ; cumulus cell; ; blood; ; renal corpuscle; ; conjunctival fornix; ; endocardial cushion; ; left colon; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	transcription coactivator activity; transcription factor binding; protein kinase B binding; NF-kappaB binding; protease binding; protein self-association; kinase binding; protein C-terminus binding; protein binding; kinase activator activity; enzyme binding; protein kinase binding; ubiquitin protein ligase binding; identical protein binding; CARD domain binding;
Cellular component	cytoplasm; cytosol; membrane; T cell receptor complex; lipopolysaccharide receptor complex; immunological synapse; perinuclear region of cytoplasm; membrane raft; cytoplasmic microtubule; lysosome; nucleus; CBM complex; protein-containing complex;
Biological process	apoptotic process; T cell apoptotic process; regulation of apoptotic process; adaptive immune response; B cell apoptotic process; regulation of T cell receptor signaling pathway; immune system process; cell death; stimulatory C-type lectin receptor signaling pathway; negative regulation of mature B cell apoptotic process; toll-like receptor signaling pathway; positive regulation of transcription, DNA-templated; Fc-epsilon receptor signaling pathway; cellular defense response; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; cellular response to mechanical stimulus; neural tube closure; response to fungus; positive regulation of T cell activation; positive regulation of NF-kappaB transcription factor activity; immunoglobulin mediated immune response; protein complex oligomerization; positive regulation of mast cell cytokine production; response to food; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of phosphorylation; response to molecule of bacterial origin; I-kappaB kinase/NF-kappaB signaling; positive regulation of protein ubiquitination; T cell receptor signaling pathway; protein homooligomerization; innate immune response; protein ubiquitination; positive regulation of apoptotic process; protein heterooligomerization; lipopolysaccharide-mediated signaling pathway; positive regulation of kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	8915
	12042
	ENSG00000142867
	ENSMUSG00000028191
	O95999
	Q9Z0H7
	NM_003921; NM_001320715
	NM_009740
	NP_001307644; NP_003912; NP_001307644.1
	NP_033870
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene. Like BCL2, BCL3, BCL5, BCL6, BCL7A, and BCL9, it has clinical significance in lymphoma.

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