Amivantamab
Amivantamab, sold under the brand name Rybrevant, is a bispecific monoclonal antibody used to treat non-small cell lung cancer. Amivantamab is a bispecific epidermal growth factor (EGF) receptor-directed and mesenchymal–epithelial transition (MET) receptor-directed antibody. It is the first treatment for adults with non-small cell lung cancer whose tumors have specific types of genetic mutations: epidermal growth factor receptor (EGFR) exon 20 insertion mutations.
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Human |
| Target | Epidermal growth factor receptor (EGFR) and Mesenchymal–epithelial transition (MET) |
| Clinical data | |
| Trade names | Rybrevant |
| Other names | JNJ-61186372, amivantamab-vmjw |
| AHFS/Drugs.com | Monograph |
| MedlinePlus | a621034 |
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| Routes of administration | Intravenous infusion |
| Drug class | Antineoplastic |
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| Identifiers | |
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| Chemical and physical data | |
| Formula | C6472H10014N1730O2023S46 |
| Molar mass | 145902.15 g·mol−1 |
The most common side effects include rash, infusion-related reactions, skin infections around the fingernails or toenails, muscle and joint pain, shortness of breath, nausea, fatigue, swelling in the lower legs or hands or face, sores in the mouth, cough, constipation, vomiting and changes in certain blood tests.
Amivantamab was approved for medical use in the United States in May 2021, and in the European Union in December 2021. The U.S. Food and Drug Administration considers it to be a first-in-class medication.