Maybe this is not what you're looking for (as it was already explained by others), but this is my solution to substitute several values at once.
def GlobalSubs(exprNames, varNames, values=[]):
if ( len(values) == 0 ): # Get the values from the
for varName in varNames: # variables when not defined
values.append( eval(varName) ) # as argument.
# End for.
# End if.
for exprName in exprNames: # Create a temp copy
expr = eval(exprName) # of each expression
for i in range(len(varNames)): # and substitute
expr = expr.subs(varNames[i], values[i]) # each variable.
# End for.
yield expr # Return each expression.
# End for.
It works even for matrices!
>>> x, y, h, k = symbols('x, y, h, k')
>>> A = Matrix([[ x, -h],
... [ h, x]])
>>> B = Matrix([[ y, k],
... [-k, y]])
>>> x = 2; y = 4; h = 1; k = 3
>>> A, B = GlobalSubs(['A', 'B'], ['x', 'h', 'y', 'k'])
>>> A
Matrix([
[2, -1],
[1, 2]])
>>> B
Matrix([
[ 4, 3],
[-3, 4]])
But don't try to make a module with this. It won't work. This will only work when the expressions, the variables and the function are defined into the same file, so everything is global for the function and it can access them.