I believe RAM consumption is identical regardless of whether it's full or empty. However more physical RAM you have in the machine the more power it will consume.
On a mac, you will want to avoid hitting the hard drive, so try to make sure you don't read the disk very often and definitely don't consume so much RAM you start using virtual memory (or push other apps into virtual memory).
Most modern macs will also partially power down the CPU(s) when they aren't very busy, so reducing CPU usage will actually reduce power consumption.