I have found that while using the <meta name="apple-mobile-web-app-capable" content="yes" /> tag in iOS 4.3.5 the <meta name="format-detection" content="telphone=no" /> tag does not work. It will work in Safari, but not if the app is launched from the home screen.
Has anyone found a working solution to this that doesn't involve adding tags to the number? (I am dynamically getting the number from a database and using it to update so this is not an option)