Before I answer this, I would just like to point out that it completely defeats the purpose of using StructureMap when you don't use interfaces. (Well, not completely, but defeats enough of the purpose of using it for me to question why you've decided to go with StructureMap in the first place...) You won't get very far in your tests without interfaces or if you do, you're going to have all of your logic sitting in one class or 20-30 classes all tightly coupled, which again is missing the point of using StructureMap. Having said that I think this should work in situations where you need to mock out a concrete class
[Test]
public void TestMethod()
{
// Arrange
var service = new RhinoAutoMocker<BusinessRuleService>();
service.PartialMockTheClassUnderTest();
service.ClassUnderTest.Expect(x => x.VirtualMethodImTesting());
// Act
service.ClassUnderTest.CallableMethod();
// Assert
service.ClassUnderTest.VerifyAllExpectations();
// ... or other stuff ...
}