I never really thought about something like that, but I guess that should be possible. On the other hand I assume you need a quite specific scenario that this would make sense as you have no common primitive available. If you are strictly staying within Skia there is no navigation and such things, which you then would need to reimplement yourself.
If you have a game that has very little logic for navigation and things that might however make sense to do.
In my experience it is usually way more reasonable to have normal RN views that are extended by a few Skia views here and there.
Interesting is that you can by now more easily add click handler to Skia views which originally was more difficult to do and you can snapshot views to use those within your Skia canvas which generally increases interoperability between standard RN and Skia quite a lot.
Do you have a specific use case in mind when asking?