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I'm looking to replicate this randomisation in R studio.

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Key features:

  • A and B are the primary comparison and must have 2 by 2 cross over design (i.e., occur togeather in each sequence)

  • The incomplete block design should include C D E and F - comparisons of interest are C vs D and E vs F. These comparisons need to occur the same number of times within the whole design, and one comparison must occur in each sequence

  • C D E F need to be balanced so that they occur the same number of times in a sequence

  • C D E F need to be balanced so that occurr the same number of times across periods

Any help would be greatly appreciated.

Many thanks.

The code I tried below is just for the incomplete block design C,D,E,F but I can't get it to balance across periods.

library(crossdes) out=find.BIB(4,20,3, iter=1)#each dosed 6 times achieving first order balance out isGYD(out)

I had then planned to join on the A and B rand.

Claire
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