I want to fit a linear mixed model (because I have repeated measures over time).
LM.fit <- lme(VR ~ Group * Time + Age + sexe + study,
random = ~1|subject,
method = "REML",
na.action = na.omit,
data = Data)
I check the assumptions (which is ok I think ?!)
BUT I have unbalanced classes in Group : Subgroup1 have 80 samples and Subgroup2 have 20 samples..
LM.fit <- lme(VR ~ Group * Time + Age + sexe + study,
random = ~1|subject,
weights = varIdent(form = ~1|Group),
method = "REML",
na.action = na.omit,
data = Data)
weights = varIdent(form = ~1|Group) I heard that adding this line can help accounting for unequal variances across groups and unbalanced classes. Can someone help me to know why and how?
If you have other methods, i am listening