Locateonscreen True then do ..... or with pixelmatch?

Question

I have a def that looks for a pixel match color if this is true it looks for an image can i replace this with locateonscreen? becorse the image position change over time

this is my def and it works but i want to use locateonscreen instead of match color for the yellowbell i changed this to the code below can this work?

    i = 0
    #while pyautogui.pixelMatchesColor(YellowBellX , YellowBellY , (YellowR,YellowG,YellowB), tolerance = 20) == True and pyautogui.pixelMatchesColor(firstTaskX , firstTaskY , (NoOrdersAviableBannerR ,NoOrdersAviableBannerG ,NoOrdersAviableBannerB ), tolerance = 20) == False:
    while pyautogui.locateOnScreen("YellowBell.png",region=(19,116,900,60), confidence=0.8) == True and pyautogui.pixelMatchesColor(firstTaskX , firstTaskY , (NoOrdersAviableBannerR ,NoOrdersAviableBannerG ,NoOrdersAviableBannerB ), tolerance = 20) == False:
        if pyautogui.pixelMatchesColor(firstTaskX , firstTaskY , (blueR,blueG,blueB), tolerance = 20) == True:
            break