Updated Answer
If you are asking whether you can alter the selection border (e.g., the blue border the WorkbookView renders in your screenshot) to only surround the top-left and bottom-rightmost cells (e.g., C3 and E5 only in your example) instead of surrounding the entire range selection (e.g., all of C3:E5), no, the behavior of how this range selection border is rendered cannot be modified in this manner.
If you are asking, apart from the range selection border, if you yourself can apply a cell border (via IRange.Borders APIs) to just these top-left / bottom-right cells, then this is possible:
IRange rangeSelection = workbookView.RangeSelection;
if (rangeSelection.CellCount > 1)
{
// Get size of range selection
int numRows = rangeSelection.RowCount;
int numCols = rangeSelection.ColumnCount;
// Create a new IRange representing only the top-left and bottom-right cells
// of the range selection.
IRange cornerCells = rangeSelection[0, 0]
.Union(rangeSelection[numRows - 1, numCols - 1]);
// Add a border to these cells.
cornerCells.Borders.Weight = BorderWeight.Medium;
}
Original answer based off original question
SpreadsheetGear supports an IRange.Subtract(...) method that will remove the specified range from another range. Example:
IRange range = worksheet.Cells["A1:B2"].Subtract(worksheet.Cells["B2"]);
Console.WriteLine(range.Address);
// OUTPUT: $A$1:$B$1,$A$2
That answers your direct question, though your description and diagrams might indicate you are asking for something beyond this but I cannot tell for sure. If so, it would help if you can update your question to use a more concrete example, providing perhaps actual screenshots of the WorkbookView or "before" and desired "after" ranges for your use-case (e.g., A1:B2 is selected and I want to change this to "..."), any actions / features in Microsoft Excel itself that provide the behavior you are looking for (which my help in determining if the same is possible in SpreadsheetGear), etc.