libtiff tools expect a filename so the background run shown below is simply from upper right X.tif to various destinations, first is default
tiff2pdf x.tif
and we can see it writes a tiff2pdf file stream to console (Standard Output) however it failed in memory without a directory to write to. However on second run we can redirect
tiff2pdf x.tif > a.pdf
or alternately specify a destination
tiff2pdf -o b.pdf x.tif
So in order to use those tools we need a File System to receive the file objects, The destination folder/file directory can be a Memory File System drive or folder.
Thus you need to initiate that first.

NuGet is a package manager simply bundling the lib and as I don't use .net your a bit out on a limb as BitMiricle are not offering free support (hence point you at Stack Overflow, a very common tech support PLOY, Pass Liability Over Yonder) however looking at https://github.com/BitMiracle/libtiff.net/tree/master/Samples
they suggest memory in some file names such as https://github.com/BitMiracle/libtiff.net/tree/master/Samples/ConvertToSingleStripInMemory , perhaps get more ideas there?