Yes. You must compile the "C" objects files to COFF format. This usually means either the Intel and/or MSVC++ compilers. The same caveats apply to 64bit object file linking that apply to 32bit. You must ensure that all external references are properly resolved, either by providing another .obj which has that symbol, or from Delphi code. When building the "C" code, make sure you disable any stack checks or other run-time verification code generation. Many times such codegen relies on a specific version of the C/C++ RTL from the given tool.
Something else worth noting is that while Delphi 64bit can link to COFF object files (eventually it will also support ELF64), 32bit Delphi supports linking with C++Builder built OMF object files and, new to XE2, 32bit COFF object files which can be built with MSVC++. The same caveats apply.